Nephroprotective activity of Macrothelypteris oligophlebia rhizomes ethanol extract

Figures & data

Table 1.  Effect of EMO on BUN, Cr, SOD, MDA, CAT, NO and GSH-Px activities in rats treated with GM.

Treatment	BUN (mmol/l)	Cr (μmol/l)	SOD (U/mg protein)	MDA (nmol/ml)	CAT (U/mg protein)	NO (μmol/ml)	GSH-Px (U/mg protein)
Control (normal saline)	5.72 ± 0.43	17.56 ± 3.32	2.94 ± 0.21	2.99 ± 0.24	10.63 ± 0.52	593.50 ± 12.19	23.33 ± 0.85
GM (100 mg/kg)	12.71 ± 1.28**	39.77 ± 5.34*	1.59 ± 0.17*	5.60 ± 0.37*	3.22 ± 0.34*	868.17 ± 22.67*	9.11 ± 1.29*
GM + EMO (250 mg/kg)	8.59 ± 0.46**	24.69 ± 2.10*	2.56 ± 0.15*	3.14 ± 0.22*	9.97 ± 0.38*	555.37 ± 17.32*	15.05 ± 3.02*
GM + EMO (500 mg/kg)	7.19 ± 0.23**	19.17 ± 0.90	2.94 ± 0.13	2.63 ± 0.24	10.57 ± 0.27	589.51 ± 8.83	20.72 ± 1.83

Values are mean ± S.D.

BUN, blood urea nitrogen; CAT, catalase; Cr, serum creatinine; EMO, ethanol extract of Macrothelypteris oligophlebia rhizomes; GM, gentamicin; GSH-Px, glutathione peroxidase; MDA, malondialdehyde; NO, nitric oxide; SOD, superoxide dismutase.

*p < 0.05 when compared with the control group.

**P < 0.01 when compared with the control group.

Figure 1.  Representative imagines of kidney from rats. (A) Control group: section shows normal tubules; (B) Gentamicin (100 mg/kg) treated group: tubule shows extensive and marked necrosis; (C) Gentamicin + EMO (250 mg/kg) treated group: tubules show limited damage; (D) Gentamicin + EMO (500 mg/kg) treated group: tubule reveals slight degenerative change. EMO, ethanol extract of Macrothelypteris oligophlebia rhizomes.