Antioxidant and cytotoxic potential of a new thienyl derivative from Tagetes erecta roots

Figures & data

Figure 1.  Structure of compound 1.

Table 1.  IC₅₀ against DPPH free radical depicting antioxidant activity and LD₅₀ against HeLa and prostate (PC-3) cancer cell lines obtained for the ethanol extract and isolates of the roots of Tagetes erecta Linn.

Extract/isolate	IC50 (µg/mL)	LD50 (µg/mL) against HeLa	LD50 (µg/mL) against PC-3
Ethanol	35.9 ± 0.35	164.28 ± 0.69	407.3 ± 0.56
T1	29.93 ± 0.11	50.15 ± 0.32	86.92 ± 0.72
T2	25.23 ± 0.16	39.36 ± 0.09	79.13 ± 0.06
T3	11.56 ± 0.18	12.5 ± 0.84	30.25 ± 0.35
T4	19.03 ± 0.71	26.81 ± 0.31	45.13 ± 0.56
T5	21.08 ± 0.36	34.64 ± 0.07	57.05 ± 0.25
T6	17.01 ± 0.97	31.25 ± 0.74	53.37 ± 0.09
T7	19.9 ± 0.55	43.27 ± 0.64	42.19 ± 0.12
T8	25.91 ± 0.23	37.22 ± 0.21	48.08 ± 0.26
T9	28.06 ± 0.09	36.25 ± 0.19	47.05 ± 0.21
T10	29.15 ± 0.82	27.81 ± 0.05	44.74 ± 0.37
T11	24.57 ± 0.91	29.13 ± 0.09	56.74 ± 0.48
T12	27.81 ± 0.07	37.28 ± 0.27	49.23 ± 0.03
T13	22.23 ± 0.14	28.17 ± 0.26	45.03 ± 0.35
T14	29.98 ± 0.85	31.03 ± 0.17	56.29 ± 0.39
T15	21.05 ± 0.83	38.87 ± 0.21	58.23 ± 0.06
T16	32.76 ± 0.67	43.02 ± 0.31	49.65 ± 0.85
T17	36.86 ± 0.34	44.21 ± 0.92	59.97 ± 0.87
T18	49.17 ± 0.88	65.22 ± 0.59	56.13 ± 0.15
T19	34.92 ± 0.27	59.28 ± 0.62	73.22 ± 0.53
T20	57.05 ± 0.98	45.13 ± 0.15	79.05 ± 0.26
T21	63.03 ± 0.86	39.14 ± 0.29	84.22 ± 0.19
Sodium ascorbate	5.32 ± 0.09	–	–
Paclitaxel	–	5.02 ± 0.75	8.56 ± 0.93

Values are mean ± standard error mean. “-” denotes not tested.

Figure 2.  Antioxidant activity of the ethanolic extract of Tagetes erecta.

Figure 3.  Cytotoxicity exhibited by the ethanolic extract of Tagetes erecta against HeLa cancer cell lines.