Protective effect of dietary flavonoid quercetin against lipemic-oxidative hepatic injury in hypercholesterolemic rats

Figures & data

Table 1.  Effect of quercetin on liver triglycerides and cholesterol in rats fed with HCD.

	Control	HCD	HCD + quercetin
Liver triglycerides (mg/g of tissue)	17.4 ± 1.2	26.7 ± 2.3^a	20.3 ± 1.9^a,b
Liver cholesterol (mg/g of tissue)	9.3 ± 0.72	14.4 ± 0.89^a	11.2 ± 0.78^a,b

Values are expressed as mean ± SD, n = 10.

Multiple comparisons were achieved using one-way ANOVA followed by Tukey–Kramer as post-ANOVA test.

^a,bindicate significant change from control and HCD groups respectively, at p < 0.05.

HCD, high cholesterol diet.

Table 2.  Effect of quercetin on the activities of liver antioxidant enzymes in rats fed with HCD.

	Control	HCD	HCD + quercetin
Catalase (mmoles of H2O2 released/min/mg protein)	8.1 ± 0.76	5.4 ± 0.46^a	7.3 ± 0.72^a,b
SOD (U/mg protein)	31.1 ± 2.8	18.8 ± 1.2^a	26.9 ± 2.1^a,b

Values are expressed as mean ± SD, n = 10.

Multiple comparisons were achieved using one-way ANOVA followed by Tukey–Kramer as post-ANOVA test.

^a,bindicate significant change from control and HCD groups respectively, at p < 0.05.

HCD, high cholesterol diet.

Figure 1.  Effect of quercetin on serum lipid profile in rats fed with HCD. Data are presented as mean ± SD, n = 10. Multiple comparisons were achieved using one-way ANOVA followed by Tukey–Kramer as post-ANOVA test. a,b: indicate significant change from control and HCD groups, respectively, at p < 0.05.

Figure 2.  Effect of quercetin on the activities of serum ALT, AST and G-GT in rats fed with HCD. Data are presented as mean ± SD, n = 10. Multiple comparisons were achieved using one way ANOVA followed by Tukey–Kramer as post-ANOVA test. a,b: indicate significant change from control and HCD groups, respectively, at p < 0.05.

Figure 3.  Effect of quercetin on the level of lipid peroxides (TBARS) in the liver of rats fed with HCD. Data are presented as mean ± SD, n = 10. Multiple comparisons were achieved using one way ANOVA followed by Tukey–Kramer as post-ANOVA test. a,b: indicate significant change from control and HCD groups respectively, at p < 0.05.

Figure 4.  Effect of quercetin on reduced glutathione (GSH) content in the liver of rats fed with HCD. Data are presented as mean ± SD, n = 10. Multiple comparisons were achieved using one-way ANOVA followed by Tukey–Kramer as post-ANOVA test. a,b: indicate significant change from control and HCD groups, respectively, at p < 0.05.

Figure 5.  Effect of quercetin on the level of nitric oxide in serum (A) and liver (B) in rats fed with HCD. Data are presented as mean ± SD, n = 10. Multiple comparisons were achieved using one-way ANOVA followed by Tukey–Kramer as post-ANOVA test. a,b: indicate significant change from control and HCD groups, respectively, at p < 0.05.