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Research Article

Protective effect of curcumin against cardiac dysfunction in sepsis rats

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Pages 482-487 | Received 06 Apr 2012, Accepted 16 Oct 2012, Published online: 22 Jan 2013

Figures & data

Figure 1.  Effect of curcumin on the body temperature of CLP rats. Rats were divided into three groups (n = 10). Groups of sham and CLP were treated with physiological saline (10 mL/kg/d, ip), group of CLP+CUM was administered with curcumin (200 mg/kg/d, 3 days, ip). The rats were observed for 72 h. *p < 0.05, compared with the sham group, and #p < 0.05, compared with the CLP group.

Figure 1.  Effect of curcumin on the body temperature of CLP rats. Rats were divided into three groups (n = 10). Groups of sham and CLP were treated with physiological saline (10 mL/kg/d, ip), group of CLP+CUM was administered with curcumin (200 mg/kg/d, 3 days, ip). The rats were observed for 72 h. *p < 0.05, compared with the sham group, and #p < 0.05, compared with the CLP group.

Figure 2.  Effect of curcumin on the cardiac function of CLP rats. Rats were divided into three groups (n = 10). A, B, C, and D represented the effect of curcumin on Ejection Fraction (EF), Fractional Shortening (FS), Cardiac Output (CO), Heart Rate, respectively. Groups of sham and CLP were treated with physiological saline (10 mL/kg/d, ip), group of CLP+CUM was administered with curcumin (200 mg/kg/d, 3 days, ip). The rats were observed for 72 h. *p < 0.05, compared with the sham group, and #p < 0.05, compared with the CLP group.

Figure 2.  Effect of curcumin on the cardiac function of CLP rats. Rats were divided into three groups (n = 10). A, B, C, and D represented the effect of curcumin on Ejection Fraction (EF), Fractional Shortening (FS), Cardiac Output (CO), Heart Rate, respectively. Groups of sham and CLP were treated with physiological saline (10 mL/kg/d, ip), group of CLP+CUM was administered with curcumin (200 mg/kg/d, 3 days, ip). The rats were observed for 72 h. *p < 0.05, compared with the sham group, and #p < 0.05, compared with the CLP group.

Figure 3.  Tissue sections of the myocardial tissues (magnification: ×400). Histological analysis of the myocardial tissues was performed by staining for H&E and examined under light microscopy. A–C represented the sham, CLP group, and CLP+CUM group, respectively.

Figure 3.  Tissue sections of the myocardial tissues (magnification: ×400). Histological analysis of the myocardial tissues was performed by staining for H&E and examined under light microscopy. A–C represented the sham, CLP group, and CLP+CUM group, respectively.

Figure 4.  The ultrastructural changes of myocardial tissues (magnification: ×10000). A–C represented the sham, CLP group, and CLP+CUM group, respectively.

Figure 4.  The ultrastructural changes of myocardial tissues (magnification: ×10000). A–C represented the sham, CLP group, and CLP+CUM group, respectively.

Figure 5.  The levels of cTn I, SOD, and MDA in plasma. Rats were divided into three groups (n = 10). Groups of sham and CLP were treated with physiological saline (10 mL/kg/d, ip), group of CLP+CUM was administered with curcumin (200 mg/kg/d, 3 days, ip). The rats were observed for 72 h. *p < 0.05, compared with the sham group, and #p < 0.05, compared with the CLP group.

Figure 5.  The levels of cTn I, SOD, and MDA in plasma. Rats were divided into three groups (n = 10). Groups of sham and CLP were treated with physiological saline (10 mL/kg/d, ip), group of CLP+CUM was administered with curcumin (200 mg/kg/d, 3 days, ip). The rats were observed for 72 h. *p < 0.05, compared with the sham group, and #p < 0.05, compared with the CLP group.

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