Anti-HIV-1 integrase compound from Pometia pinnata leaves

Figures & data

Table 1. Plant materials used in this study.

Botanical name	Family	Voucher number	Part used
Averrhoa carambola L.	Oxalidaceae	SKP 135 01 03 01	Leaves
Garcinia cowa Roxb. ex DC.	Guttiferae	SKP 083 07 03 01	Leaves
Murraya paniculata (L.) Jack.	Rutaceae	SKP 166 13 16 01	Leaves
Pandanus amaryllifolius Roxb.	Pandanaceae	SKP 138 16 01 01	Leaves
Pometia pinnata J. R. Forst. & G. Forst	Sapindaceae	SKP 171 16 10 01	Leaves
Sauropus androgynus (L.) Merr.	Euphorbiaceae	SKP 071 19 01 01	Leaves
Tiliacora triandra (Colebr.) Diels.	Menispermaceae	SKP 114 20 20 01	Leaves
Vigna unguiculata (L.) Walp. subsp. unguiculata	Leguminosae	SKP 098 22 19 01	Leaves

Table 2. Anti-HIV-1 IN activity of the selected Thai medicinal plants.

Plant extracts/compound	IC50 (µg/mL) ± SD
Averrhoa carambola	47.6 ± 0.24
Garcinia cowa	75.5 ± 0.28
Murraya paniculata	n.a.
Pandanus amaryllifolius	n.a.
Pometia pinnata	8.8 ± 0.27
Sauropus androgynus	n.a.
Tiliacora triandra	n.a.
Vigna unguiculata	n.a.
Suramin (positive control)	3.4 ± 0.1

IC₅₀ values are expressed as mean ± SD (n = 4); n.a. = not active at 100 µg/mL.

Figure 1. Chemical structures of compounds isolated from P. pinnata leaves.