Antiplasmodial potential of extracts from two species of genus Blumea

Figures & data

Figure 1. Chemical fingerprint of aerial part (A) and root (B) ethanol extract of B. membranacea.

Figure 2. Chemical fingerprint of aerial part (A) and root (B) ethanol extract of B. eriantha.

Table 1. In vitro antiplasmodial activity and safety profile of various extracts of B. membranacea and B. eriantha.

Sl. no.	Sample name	Anti-malarial^a (IC50 µg/mL)	Toxicity^b (IC50 µg/mL)	Selectivity index (SI)^c
1	MA	55.0
2	MA1	17.4	>200	>11.494
3	MA2	19.0	>200	>10.526
4	MA3	>200.0
5	MR	100.0
6	MR1	57.5
7	MR2	141.0
8	MR3	3.3	>200	>60.606
9	EA	94.0
10	EA1	25.0	>200	>8.000
11	EA2	26.5	180	6.792
12	EA3	189.0
13	ER	75.5
14	ER1	156.0
15	ER2	15.6	106	6.794
16	ER3	61.5
17	CQ	0.024
18	DR		1.3

CQ = Chloroquine; DR = Doxorubicin.

^aAgainst NF-54 Plasmodium falciparum strain; ^bagainst mammalian cell line (Vero); ^cSI = IC₅₀ (Vero)/IC₅₀ (antiplasmodial).

Figure 3. In vitro antiplasmodial activity of extracts and fractions of B. membranacea and B. eriantha.