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Research Article

Antinociceptive activity of Ligusticum porteri preparations and compounds

, , , &
Pages 14-20 | Received 14 Feb 2013, Accepted 09 May 2013, Published online: 04 Oct 2013

Figures & data

Figure 1. Chemical structures of compounds 13.

Figure 1. Chemical structures of compounds 1–3.

Figure 2. Antinociceptive activity of L. porteri herbal preparations: organic extract (OE), aqueous extract (AE) and essential oil (EO) in the writhing test. DIP: dipyrone (100 mg/kg). Data are presented as mean ± SEM (n = 6). *p < 0.05, **p < 0.01 and ***p < 0.001, Dunnett’s post hoc test compared with control group.

Figure 2. Antinociceptive activity of L. porteri herbal preparations: organic extract (OE), aqueous extract (AE) and essential oil (EO) in the writhing test. DIP: dipyrone (100 mg/kg). Data are presented as mean ± SEM (n = 6). *p < 0.05, **p < 0.01 and ***p < 0.001, Dunnett’s post hoc test compared with control group.

Figure 3. Antinociceptive activity of L. porteri herbal preparations: organic extract (OE), aqueous extract (AE) and essential oil (EO) in the hot-plate test. MOR: morphine (5 mg/kg). Data are presented as mean ± SEM (n = 6). *p < 0.05, **p < 0.01 and ***p < 0.001, Dunnett’s post hoc test compared with control group.

Figure 3. Antinociceptive activity of L. porteri herbal preparations: organic extract (OE), aqueous extract (AE) and essential oil (EO) in the hot-plate test. MOR: morphine (5 mg/kg). Data are presented as mean ± SEM (n = 6). *p < 0.05, **p < 0.01 and ***p < 0.001, Dunnett’s post hoc test compared with control group.

Figure 4. Antinociceptive activity of 1 and 2 in the hot-plate test. MOR: morphine (5 mg/kg). Data are presented as mean ± SEM (n = 6). *p < 0.05, **p < 0.01 and ***p < 0.001, Dunnett’s post hoc test compared with control group.

Figure 4. Antinociceptive activity of 1 and 2 in the hot-plate test. MOR: morphine (5 mg/kg). Data are presented as mean ± SEM (n = 6). *p < 0.05, **p < 0.01 and ***p < 0.001, Dunnett’s post hoc test compared with control group.

Figure 5. Antinociceptive activity of compounds 13 in the writhing test. DIP: dipyrone (100 mg/kg). Data are presented as mean ± SEM (n = 6). *p < 0.05, **p < 0.01 and ***p < 0.001, Dunnett’s post hoc test compared with control group.

Figure 5. Antinociceptive activity of compounds 1–3 in the writhing test. DIP: dipyrone (100 mg/kg). Data are presented as mean ± SEM (n = 6). *p < 0.05, **p < 0.01 and ***p < 0.001, Dunnett’s post hoc test compared with control group.

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