Figures & data
Figure 1. Effect of the hydro-alcoholic extract from the aerial parts of Nasturtium officinale (250, 500 and 750 mg/kg) and indomethacin (10 mg/kg) on carrageenan-induced paw edema in rats. Each point represents the mean ± S.E.M of six animals; ***p < 0.001 statistically significant compared to their respective control.
Figure 2. Effect of the hydro-alcoholic extract from the aerial parts of Nasturtium officinale (500 mg/kg) and indomethacin (10 mg/kg) on formalin-induced paw edema in rats. Each point represents the mean ± S.E.M of six animals; ***p < 0.001 statistically significant compared to their respective control.
Figure 3. Effect of hydro-alcoholic extract from the aerial parts of Nasturtium officinale (1 mg/ear, 2 mg/ear and 5 mg/ear) and indomethacin (0.5 mg/ear) on TPA-induced ear edema in mice. Data represent mean ± S.E.M. of six animals; *p < 0.05 and ***p < 0.001 statistically significant compared to their respective control.
Figure 4. (a) Histological changes in rat paws after sub-plantar injection of carrageenan. (A) Normal paw. (B) Carrageenan-induced edema, and infiltration of leukocytes especially neutrophil. (C) Indomethacin (10 mg/kg, oral.) decreased paw swelling and infiltration of neutrophil. Oral pretreatment of rats with Nasturtium officinale at 250 (D), 500 (E) and 750 (F) mg/kg doses inhibited development of edema and migration of neutrophils, compared with carrageenan-treated paw. (b) Pathological examination of ear tissues after topical application of TPA. (A) Normal ear, (B) Control: Topical application of TPA (2.5 mg/ear) induced inflammatory lesion with edema and epidermal hyperplasia. (C) Topical application of the extract from the aerial parts of Nasturtium officinale (5 mg/ear) immediately after TPA reduced edema and epidermal hyperplasia induced by TPA. (D) Indomethacin (0.5 mg/ear) also decreased edema and ear hyperplasia. Sections were stained with hematoxyline and eosin, magnification ×20.
