Zizyphus jujuba protects against ibuprofen-induced nephrotoxicity in rats

Figures & data

Table 1. Effects of IBP and/or ZE treatments on body weight in rats.

Parameter	Saline	ZE	IBP	ZE + IBP
Initial body weight (g)	185.00 ± 5.77	178.33 ± 4.41	176.67 ± 6.67	178.33 ± 4.41
Final body weight (g)	200.00 ± 5.77	200.00 ± 2.89	166.67 ± 7.26	186.67 ± 4.41
Relative gain (%)	8.12 ± 0.25	12.31 ± 3.62^a	−5.7 1 ± 1.72^b	5.67 ± 0.65^a

Data shown as mean ± SEM. Different letters in the same row are significantly different (p < 0.05).

^aSignificantly different from the IBP group.

^bSignificantly different from the saline group.

Table 2. Effects of IBP and/or ZE treatments on some serum biochemical parameters in rats.

Parameter	Saline	ZE	IBP	ZE + IBP
Urea (mg/dl)	40.70 ± 4.72	40.00 ± 3.53^a	94.24 ± 15.98^b	40.50 ± 1.33^a
Creatinine (µmol/l)	48.39 ± 1.89	42.48 ± 4.33^a	90.18 ± 14.03^b	54.03 ± 3.55^a
Albumin (g/dl)	3.87 ± 0.13	3.96 ± 0.12^a	2.69 ± 0.10^b	3.42 ± 0.13^a
Total protein (g/dl)	5.59 ± 0.18	5.56 ± 0.45^a	3.39 ± 0.25^b	5.27 ± 0.12^a

Data shown as mean ± SEM. Different letters in the same row are significantly different (p < 0.05).

^aSignificantly different from the IBP group.

^bSignificantly different from the saline group.

Table 3. Effects of IBP and/or ZE treatments on some antioxidant enzymes in rats.

Parameter	Saline	ZE	IBP	ZE + IBP
CAT (µmol/min/mg protein)	216 ± 16.5	367.33 ± 5.90^a	361.67 ± 19.01^a	397.67 ± 28.14^a
GST (nmol/min/mg protein)	167.33 ± 2.60	226.67 ± 17.03^a	284.00 ± 7.77^b	373.67 ± 11.09^b
SOD (U/mg protein)	48.67 ± 4.41	75.33 ± 4.67^a	34.00 ± 3.51	56.00 ± 4.16^a
MDA (µmol/min/mg protein)	1.93 ± 0.15	1.89 ± 0.12	1.41 ± 0.13	1.76 ± 0.12

Data shown as mean ± SEM.

^aSignificantly different from the saline group (p < 0.05).

^bSignificantly different from the saline group (p < 0.001).

Figure 1. Micrographs of rat kidney tissues: (A) Saline group, normal morphology; (B) ZE group, similar structure as saline group with normal tubules and glomeruli; (C) IBP-treated group, hypercellularity in some and shrinkage in other glomeruli lines, ischemia in proximal convoluted tubules and congestion and (D) ZE + IBP-treated group, normal morphology of tubules and glomeruli as saline group.