Phytochemical and antitrypanosomal investigation of the fractions and compounds isolated from Artemisia elegantissima

Figures & data

Figure 1. Structures of compounds 1–13.

Table 1. Preliminary antitrypanosomal activities of the fractions obtained from the aerial parts of A. elegantissima.

		T.b. brucei^a % of D control
S. no	Fractions	20 µg/ml	10 µg/ml	5 µg/ml
1	A	22.9	82.5	91.5
2	B	7.4	1.8	11.4
3	C	5.7	0.3	2.4
4	D	−6.7	−10.5	81.4
5	E	−6.0	−2.4	86.3
6	F	−3.5	−5.7	2.1

D, DMSO.

^aT.b. brucei, Trypanosoma brucei brucei.

Table 2. Preliminary antitrypanosomal activities of the compounds isolated from the aerial parts of A. elegantissima.

S. no.	Compounds	T.b. brucei % of D control 20 µg/ml	T.b. brucei % of D control 10 µg/ml	T.b. brucei MIC µg/ml
1	p-Hydroxy cinnamic acid (1)	93.2	99.7	NT^a
2	β-Sitosterol (2)	101.5	105.0	NT^a
3	Stigmasterol (3)	101.5	105.0	NT^a
4	Betulinic acid (4)	99.1	104.3	NT^a
5	bis-Dracunculin (5)	85.3	87.2	NT^a
6	Dracunculin (6)	89.0	106.2	NT^a
7	Scopoletin (7)	−0.4	−0.4	<0.19
8	Dihydroluteolin (8)	93.4	98.0	NT^a
9	Apigenin (9)	44.2	91.3	NT^a
10	Nepetin (10)	39.6	87.2	NT^a
11	Scopolin (11)	37.2	85.5	NT^a
12	Bonanzin (12)	−0.5	98.6	20
13	3′,4′-Dihydroxy bonanzin (13)	−0.8	−1.2	6.25

D, DMSO.

^aNT, not tested.