Ethanol extract of Butea monosperma bark modulates dyslipidemia in streptozotocin-induced diabetic rats

Figures & data

Table 1. Effect of Butea monosperma bark on body weight, serum glucose, plasma insulin, and glycosylated hemoglobin in normal and diabetic rats.

Experimental group	Body weight (g)	Glucose (mg/dL)	Insulin (ng/mL)	Glycosylated hemoglobin (%)
I	239.1 ± 21.9	98.7 ± 8.9	3.2 ± 0.3	5.2 ± 0.6
II	242.3 ± 22.1	88.2 ± 8.0	3.9 ± 0.4	5.0 ± 0.5
III	178.4 ± 16.3^a	402.1 ± 36.7^a	1.6 ± 0.1^a	12.9 ± 1.2^a
IV	221.4 ± 20.2^b	238.1 ± 19.1^b	2.2 ± 0.2^b	9.6 ± 0.9^b

The data are expressed as mean ± SD.

^ap < 0.05 compared to the normal control group.

^bp < 0.05 compared to the diabetic control group.

Figure 1. Effect of Butea monosperma bark on lipid profile in normal and diabetic rats. The data are expressed as mean ± SD. ^ap < 0.05 compared to the normal control group; ^bp < 0.05 compared to the diabetic control group.

Figure 2. Effect of Butea monosperma bark on apolipoproteins in normal and diabetic rats. The data are expressed as mean ± SD. ^ap < 0.05 compared to the normal control group; ^bp < 0.05 compared to the diabetic control group.

Figure 3. Effect of Butea monosperma bark on HMG CoA reductase in normal and diabetic rats. The data are expressed as mean ± SD. ^ap < 0.05 compared to the normal control group; ^bp < 0.05 compared to the diabetic control group.

Figure 4. Effect of Butea monosperma bark on malic enzyme in normal and diabetic rats. The data are expressed as mean ±SD. ^ap < 0.05 compared to the normal control group; ^bp < 0.05 compared to the diabetic control group.

Figure 5. Effect of Butea monosperma bark on isocitrate dehydrogenase in normal and diabetic rats. The data are expressed as mean ± SD. ^ap < 0.05 compared to the normal control group; ^bp < 0.05 compared to the diabetic control group.

Figure 6. Effect of Butea monosperma bark on glucose 6-phosphate dehydrogenase in normal and diabetic rats. The data are expressed as mean ± SD. ^ap < 0.05 compared to the normal control group; ^bp < 0.05 compared to the diabetic control group.

Table 2. Effect of Butea monosperma bark on liver function tests in normal and diabetic rats.

Experimental group	SGOT (U/L)	SGPT (U/L)	ACP (U/L)	ALP (U/L)
I	35.5 ± 3.2	26.2 ± 2.4	4.4 ± 0.4	28.7 ± 2.6
II	34.7 ± 3.2	25.9 ± 2.7	4.3 ± 0.4	27.6 ± 2.5
III	69.1 ± 6.4^a	50.1 ± 4.5^a	7.0 ± 0.6^a	54.2 ± 4.9^a
IV	50.9 ± 4.7^b	37.8 ± 3.4^b	5.4 ± 0.5^b	44.3 ± 4.0^b

The data are expressed as mean ± SD.

^ap < 0.05 compared to the normal control group.

^bp < 0.05 compared to the diabetic control group.

Figure 7. Histopathology of liver of experimental rats. (A) Group I – Normal histology showing hepatocytes (H) and portal triad (PT); (B) Group II – Normal histology showing hepatocytes (H) and portal vein (PV); (C) Group III – Diabetic liver showing dialated sinusoids (DS) and haemorrhage; (D) Group IV – Diabetic liver showing mild degeneration of hepatocytes (H).