Figures & data
Figure 1. Delayed toxicity of diazepam and amiodarone on the viability of EVC304 cells. The cells were exposed to a high concentration of the drugs for a period of 20 min. The drugs were removed, and the delayed toxicity was evaluated at 24 h (A) and 48 h (B). *p < 0.05 and **p < 0.01 compared with the normal control group.
Figure 2. Effects of diazepam and amiodarone on the intracellular LDH activity after short-term (20 min) exposure. *p < 0.05 and **p < 0.01 compared with the normal control group.
Figure 3. Effects of diazepam and amiodarone on the intracellular G6PD activity after short-term (20 min) exposure. *p < 0.05 and **p < 0.01 compared with the normal control group.
Figure 4. Effects of diazepam and amiodarone on the intracellular ATP concentration after short-term (20 min) exposure. **p < 0.01 compared with the normal control group.
Figure 5. Effects of diazepam and amiodarone on the intracellular GSH concentration after short-term (20 min) exposure. *p < 0.05 and **p < 0.01 compared with the normal control group.
Figure 6. Comparison of the EC50 values of diazepam and amiodarone determined through the ATP, G6PD, GSH, and LDH assays. **p < 0.01 compared with the diazepam group.
