Figures & data
Figure 1. Chemical structures of active components of S. miltiorrhiza.
Figure 2. Effect of S. miltiorrhiza active components or ethanol extracts on liver function of rats suffering acute liver injury. Indicated compounds or extracts were administered to rats for five consecutive days. Acute liver injury was induced by carbon tetrachloride (CCl4; 0.75 mL/kg, p.o.) given once after the last dose of the indicated agent. ALB, ALP, ALT, AST, and BIL-T levels in serum were tested. Values are means ± SD. Each group contained at least 10 rats. *p < 0.05 indicates a significant difference from rats treated with CCl4 alone.
Figure 3. Effect of S. miltiorrhiza active components or ethanol extract on serum cytokine levels in rats suffering acute liver injury. Indicated drugs or extracts were administered to rats for five consecutive days. Acute liver injury was induced by carbon tetrachloride (CCl4; 0.75 mL/kg, p.o.) given once after the last dose of the indicated agent. IL1, IL6, and TNF concentration in serum are expressed as means ± SD. Each group contained at least 10 rats. *p < 0.05 indicates a significant difference from rats treated with CCl4 alone.
Figure 4. Effect of S. miltiorrhiza active components or ethanol extracts on the p38 pathway in Kupffer cells. Kupffer cells were treated with the indicated compounds or extracts at the indicated concentrations for 24 h as described in Materials and methods. Western blots were used to test p38 and p-p38 expression. The band density was quantified with Total lab software. *p < 0.05, compared with cells treated with LPS alone.
Figure 5. Effect of S. miltiorrhiza active components or ethanol extracts on the NFκB pathway in Kupffer cells. Kupffer cells were treated with the indicated compounds or extracts at the indicated concentrations for 24 h as described in Materials and methods. Western blot was used to test NFκBp65, IκB, and p-NFκBp65 expression. The band density was quantified as for . *p < 0.05, compared with cells treated with LPS alone.
Figure 6. Effect of S. miltiorrhiza active components or ethanol extracts on c-fos expression in Kupffer cells. Kupffer cells were treated as for and . Western blot was used to test c-fos expression. The band density of bands was quantified as for . *p < 0.05, compared with cells treated with LPS alone.
