Cytotoxic activity of the alkaloids from Broussonetia papyrifera fruits

Figures & data

Figure 1. Structures of seven isoquinoline alkaloids from B. papyrifera fruits.

Figure 2. Cytotoxic activity of B. papyrifera fruits total alkaloids and the seven individual isoquinoline alkaloids against three different tumor cell lines (A) BEL-7402, (B) A375, (C) Hela, and (D) human skin epidermal cells. The values of the cell survival represent the means of triplicate independent cultures with standard deviations.

Table 1. IC₅₀ values (μg/mL) of total alkaloid and seven isoquinoline alkaloids from B. papyrifera fruits against different cell lines after 48 h incubation.

	Cell lines
Compound	Epidermal cells	A375	BEL-7402	Hela
Total alkaloid	NS	22.14 ± 2.95	17.42 ± 1.51	9.82 ± 1.43
N-Norchelerythrine	NS	NS	20.23 ± 1.87	40.17 ± 1.03
Dihydrosanguinarine	NS	NS	36.77 ± 2.19	27.14 ± 0.96
Oxyavicine	NS	26.33 ± 1.88	47.41 ± 4.98	20.00 ± 1.40
Broussonpapyrine	19.91 ± 1.44	13.95 ± 0.64	14.46 ± 0.91	20.35 ± 2.15
Nitidine	18.01 ± 0.47	12.45 ± 0.76	16.11 ± 0.48	17.20 ± 2.03
Chelerythrine	22.31 ± 1.99	6.81 ± 0.99	8.41 ± 0.64	6.62 ± 0.61
Liriodenine	NS	5.38 ± 0.27	6.61 ± 0.57	5.97 ± 0.39
HCPT	NS	8.34 ± 0.89	8.90 ± 0.82	9.13 ± 0.66

NS, no significant activity. IC₅₀ > 50 μg/mL.