Ameliorative effect of methanol extract of Rumex vesicarius on CCl₄-induced liver damage in Wistar albino rats

Figures & data

Table 1. Effect of the methanolic extract of R. vesicarius on AST, ALT, and ALP levels in serum.

Treatment	AST (IU/l)	ALT (IU/l)	ALP (IU/l)
I (normal control)	146.50 ± 7.57	62.08 ± 1.96	386.25 ± 11.55
II (CCl4 only)	667.50 ± 19.89*	217.40 ± 18.66*	702.25 ± 27.80*
III (MERV-100 mg/kg + CCl4)	275.25 ± 15.04#	110.60 ± 10.65#	536.75 ± 15.32#
IV(MERV-200 mg/kg + CCl4)	230.01 ± 13.21#	82.15 ± 5.01#	504.75 ± 19.72#
V (MERV-200 mg/kg)	139.54 ± 9.62	57.92 ± 2.13	378.74 ± 21.28
VI (silymarin-100 mg/kg + CCl4)	225.75 ± 17.15#	80.70 ± 3.68#	465.75 ± 8.91#

AST, aspartate transaminase; ALT, alanine transaminase; ALP, alkaline phosphatase.

*p < 0.01 as compared with the normal control group.

#p < 0.01 as compared with the CCl₄ only treated group.

Table 2. Effect of the methanolic extract of R. vesicarius on LPO and GSH levels in liver.

Treatment	LPO (nmol of MDA formed/ min/g tissue)	GSH (µmoles/g tissue)
I (normal control)	1.91 ± 0.06	0.22 ± 0.02
II (CCl4 only)	7.41 ± 0.30*	0.07 ± 0.01*
III (MERV-100 mg/kg + CCl4)	3.61 ± 0.38#	0.30 ± 0.02#
IV (MERV-200 mg/kg + CCl4)	3.38 ± 0.33#	0.34 ± 0.04#
V (MERV-200 mg/kg)	1.94 ± 0.13	0.23 ± 0.02
VI (silymarin-100 mg/kg + CCl4)	3.12 ± 0.22#	0.35 ± 0.05#

LPO, lipid peroxidation; GSH, total glutathione.

*p < 0.01 as compared with the normal control group.

#p < 0.01 as compared with the CCl₄ only treated group.

Figure 1. Normal control group rat liver section showing normal cellular architecture with distinct hepatic cells and sinusoidal space.

Figure 2. Toxic control group rat liver section showing disarrangement and degeneration of normal hepatic cells with intense centrilobular necrosis.

Figure 3. CCl₄ + MERV-100 mg/kg-treated group rat liver section showing moderate hepatoprotective activity.

Figure 4. CCl₄ + MERV-200 mg/kg-treated group rat liver section showing typical lobular arrangement.

Figure 5. MERV per se group rat liver section showing normal pattern of histological architecture.

Figure 6. CCl₄ + silymarin-100 mg/kg-treated group rat liver section showing less disarrangement and degeneration of hepatocytes.