Hypolipidemic effects of Solidago chilensis hydroalcoholic extract and its major isolated constituent quercetrin in cholesterol-fed rats

Figures & data

Table 1. The liver weight/body weight ratios of rats subjected to a hyperlipidemic diet (mean ± SD) (n = 6).

		Body weight (g)
Groups	Initial	15 d	45 d	Liver weight (g)	Ratio between the weights
N	274.1 ± 17.9	337.4 ± 25.5	397.8 ± 31.2	12.7 ± 1.4	3.2 ± 0.3
C	254.7 ± 28.8	325.3 ± 39.1	383.1 ± 50.1	20.1 ± 2.0*	4.9 ± 0.3*
HE 150	258.9 ± 18.9	320.3 ± 34.6	346.7 ± 41.0	16.7 ± 1.4*#	4.9 ± 0.3*
HE 300	266.6 ± 20.4	337.5 ± 29.9	360.3 ± 28.3	16.8 ± 1.1*#	4.7 ± 0.2*
HE 600	259.2 ± 18.4	326.9 ± 28.3	356.0 ± 28.9	16.7 ± 1.0*#	4.7 ± 0.2*
QRT	270.9 ± 18.7	337.9 ± 28.5	392.4 ± 38.4	16.6 ± 1.3*#	4.3 ± 0.1*&
SIMV	251.0 ± 20.6	322.5 ± 26.8	375.8 ± 48.8	15.6 ± 1.1*#	4.3 ± 0.1*&

Groups: N, normal; C, control; HE, hydroalcoholic extract (150, 300, and 600 mg/kg); QRT, quercetrin; SIMV, simvastatin.

*p < 0.005, compared with group N; #p < 0.005 compared with group C; &p < 0.005, compared with groups C and N.

Figure 1. The effects of treatments on TC, LDL-C, and TG values (mean ± SD) (n = 6). Rats were either given a normal diet (N) or the following treatments with a high-fat diet: water (C); 150, 300, and 600 mg/kg Solidago chilensis hydroalcoholic extracts (150, 300, and 600); quercetrin (QRT); and simvastatin (4 mg/kg) (SIMV). ANOVA one-way *p < 0.0001 compared with the group N. #p < 0.005 compared with the group C.

Table 2. The effects of the treatments on atherogenic index values, VLDL, and ALT enzymatic activity (n = 6) (mean ± SD).

Groups	Atherogenic index	VLDL (mg/dL)	ALT (U/L)
N	1.8 ± 0.2	16.5 ± 1.0	43.2 ± 2.8
C	4.5 ± 0.3*	21.7 ± 1.7*	42.7 ± 7.8
HE 150	2.6 ± 0.3#	18.4 ± 0.5	41.5 ± 4.6
HE 300	2.8 ± 0.5*#	17.0 ± 1.4&	43.5 ± 6.0
HE 600	2.8 ± 0.5*#	15.7 ± 2.2&	45.3 ± 5.6
QRT	2.5 ± 0.5#	16.0 ± 1.5&	42.0 ± 5.2
SIMV	3.0 ± 0.3*#	14.0 ± 3.9&	41.2 ± 5.3

N, normal; C, control; HE, hydroalcoholic extract (150, 300, and 600 mg/kg); QRT, quercetrin; SIMV, simvastatin.

*p < 0.005, compared with group N; #p < 0.0001 compared with group C; &p < 0.005, compared with group C.

Figure 2. Index of inhibition of activity HMG-CoA reductase of the animals (mean values ± SD) (n = 6). Rats were either given a normal diet (N) or the following treatments with a high-fat diet: water (C); 150, 300, and 600 mg/kg Solidago chilensis hydroalcoholic extracts (150, 300, and 600); quercetrin (QRT); and simvastatin (4 mg/kg) (SIMV). *p < 0.005 compared with the group N. #p < 0.005 compared with the group C.

Figure 3. The effects of the treatments on cholesterol excretion in feces (data shown represent mean values ± SD) (n = 6). Rats were either given a normal diet (N) or the following treatments with a high-fat diet: water (C); 150, 300, and 600 mg/kg Solidago chilensis hydroalcoholic extracts (150, 300, and 600); quercetrin (QRT); and simvastatin (4 mg/kg) (SIMV). *p < 0.0001 compared with the group N. #p < 0.0001 compared with the group C. &p < 0.0001 compared with the groups HE 150, HE 300 and QRT.

Figure 4. The effects of the treatments on liver lipid peroxidation (data shown represent mean values ± SD) (n = 6). Rats were either given a normal diet (N) or the following treatments with a high-fat diet: water (C); 150, 300, and 600 mg/kg Solidago chilensis hydroalcoholic extracts (150, 300, and 600); quercetrin (QRT); and simvastatin (4 mg/kg) (SIMV). *p = 0.0016 compared with the N group.