Figures & data
Figure 1. Effects of intraperitoneal (A) ellagic acid (EA; 0.3–10 mg/kg) or (B) carbamazepine (CBZ; 3–30 mg/kg) in the mouse acetic acid-induced writhing test. Data are the mean ± SEM of 8–10 animals per group (one-way ANOVA followed by Tukey’s test). **p < 0.01, ***p < 0.001 versus the vehicle (VEH) control group.
Figure 2. Dose–response curves for the antinociception induced by ellagic acid (EA; i.p.), carbamazepine (CBZ; i.p.) alone and in combination in the mouse acetic acid-induced writhing test. Data are the mean ± SEM of 10–12 animals per group.
Figure 3. Isobologram for the co-administration of ellagic acid (EA, i.p.) and carbamazepine (CBZ; i.p.) on acetic acid-induced writhing in mice. Horizontal lines in the abscissa and the ordinate represent the S.E.M. of the corresponding ED50. Filled circles correspond to the theoretical and experimental ED50 values with 95% confidence intervals.
