Figures & data
Figure 1. The chemical structure of 2,7-dihydroxy-3-methylanthraquinone (DDMN).
Figure 2. Anti-proliferation effect of DDMN on SGC-7901 cells. **p < 0.01, compared with the control.
Figure 3. Effect of DDMN on apoptosis of SGC-7901cells. (A–D) Separately stood for control, 10 μM, 20 μM, and 40 μM.
Figure 4. Effect of DDMN on expression of anti-apoptotic protein including Mcl-1, Bcl-xl, and Bcl-2 in SGC-7901 cells. *p < 0.05, **p < 0.01, compared with the control.
Figure 5. Effect of DDMN on expression of pro-apoptotic protein including Bax, Bak, and Bad in SGC-7901 cells. *p < 0.05, **p < 0.01, compared with the control.
Figure 6. Effect of DDMN on expression of cytochrome c in SGC-7901 cells. Cytochrome c (C) and cytochrome c (M), respectively, represented cytochrome c in cytoplasm and cytochrome c in mitochondria. **p < 0.01, compared with the control.
Figure 7. Effect of DDMN on levels of caspase-3 and caspase-9 in SGC-7901 cells. *p < 0.05, **p < 0.01, compared with the control.
Figure 8. Effect of DDMN on tumor volumes and body weight of nude mice in the SGC-7901 cells-caused xenograft model. *p < 0.05, **p < 0.01, compared with the control.
Figure 9. Effect of DDMN on expression of anti-apoptotic protein including Mcl-1, Bcl-xl, and Bcl-2 in the SGC-7901 cells-caused xenograft model. **p < 0.01, compared with the control.
Figure 10. Effect of DDMN on expression of pro-apoptotic protein including Bax, Bak, and Bad in the SGC-7901 cells-caused xenograft model. *p < 0.05, **p < 0.01, compared with the control.
Figure 11. Effect of DDMN on expression of caspase-3 and caspase-9 in the SGC-7901 cells-caused xenograft model. **p < 0.01, compared with the control.
