Cardiac troponin I in congenital heart defects with pressure or volume overload

Figures & data

Table I. Data on healthy control children and patients according to the type of congenital heart defect at baseline. Values are median (range).

	Controls	ASD	PDA	CoA	PS	AS
N	74	41	37	40	10	10
Age (years)	5.4 (0.0–15.6)	6.4 (2.3–18.5)	2.3 (0.6–10.6)	6.2 (0.0–19.0)	0.1 (0.0–8.4)	0.2 (0.0–6.5)
Female/Male	31/43	9/32	13/24	26/14	8/2	7/3
Weight (kg)	20.0 (3.1–66.5)	22.0 (12.4–64.7)	13.0 (5.0–32.8)	23.8 (2.7–73)	4.5 (3.0–25.4)	6.6 (2.7–15.4)
Height (cm)	114 (48–175)	118 (83–164)	88 (61–141)	123 (48–187)	56 (49–126)	64 (44–109)

ASD = atrial septal defect, PDA = patent ductus ateriosus, CoA = coarctation of aorta, PS = stenosis of pulmonary valve, AS = stenosis of aortic valve.

Table II. Characteristics of healthy controls and patients in subgroups according to loading conditions at baseline. The pressure-overload group comprised children with coarctation of the aorta, aortic valve stenosis, or pulmonary valve stenosis. The volume-overload group comprised children with atrial septal defect or patent ductus arteriosus. Values are median (range).

	Controls	Pressure overload	Volume overload
N	74	60	78
age (years)	5.4 (0.0–15.6)	0. 7 (0.0–19.0)*	3.9 (0.6–18.5)§
weight (kg)	20.0 (3.1–66.5)	10.7 (2.7–73.0)*	16.8 (5.0–64.7)§
height (cm)	114 (48–175)	74 (44–187)*	103 (61–164)§
ANPN (nmol/l)	0.30 (0.10–1.60)	0.63 (0.10–36.00)†	0.41 (0.11–4.90)†‡
NT-proBNP (ng/l)	68 (14–3224)	167 (4–35001)†	107 (5–6027)†§

ANPN = N-terminal proatriopeptide, NT-proBNP = N-terminal pro-brain natriuretic peptide.

*P < 0.001 as compared with controls.

†P < 0.05 as compared with controls.

‡P < 0.001 as compared with patients with pressure overload.

§P < 0.05 as compared with patients with pressure overload.

Table III. Comparison of children with pressure overload and baseline positive or negative levels of cardiac troponin I. Values are median (range).

	TnI +	TnI +	P
N	12	48
age (years)	0.0 (0.0–13.0)	3.5 (0.0–19.0)	< 0.001
weight (kg)	3.7 (2.7–43.9)	15.5 (2.7–73)	< 0.001
ANPN (nmol/l)	11.61 (0.53–36.00)	0.53 (0.10–11.00)	< 0.001
NT -proBNP (ng/l)	35001 (53–35001)	103 (4–19527)	< 0.001
stenosis gradient (mm Hg)	54 (23–146)	33 (0–110)	0.019

ANPN = N-terminal proatriopeptide, NT-proBNP = N-terminal pro-brain natriuretic peptide.