Atrial fibrillation and biomarkers of myocardial fibrosis in heart failure

Figures & data

Figure 1. The relations between carboxy-terminal propeptide of procollagen type I (PICP, n = 131; upper panel) and carboxy-terminal telopeptide of collagen type-I (CITP, n = 123; lower panel), and left atrial size.

Table I. Clinical characteristics in 143 heart failure patients.

	Atrial fibrillation	Sinus rhythm	P
n	77	66	–
Age, years	76 ± 7	74 ± 7	0.095
Female, n (%)	36 (47)	25 (38)	0.28
Systolic blood pressure, mm Hg	132 ± 25	134 ± 25	0.66
Diastolic blood pressure, mm Hg	79 ± 16	80 ± 13	0.78
Hypertension, n (%)	18 (24)	23 (35)	0.140
Coronary artery disease, n (%)	44 (59)	46 (71)	0.135
Diabetes mellitus, n (%)	13 (17)	19 (30)	0.105
New York Heart Association Class 1/2/3/4, n (%)	0/51/24/2 (0/66/31/3)	0/40/26/0 (0/61/39/0)	0.188
PICP, μg/L	85 ± 38	77 ± 38	0.080
CITP, μg/L	8.0 ± 6.1	8.4 ± 5.3	0.66
BNP, pg/L	175 [76; 381]	247 [104; 434]	0.121
C-reactive protein, mg/L	6 [3; 12]	8 [2; 12]	0.55
Estimated glomerular filtration rate, mL/min/m^2	58 ± 16	55 ± 14	0.27
LV mass index, g/m^2	129 ± 37	152 ± 44	0.004
LV ejection fraction, %	37 ± 10	30 ± 11	< 0.001
End-diastolic volume, mL	100 ± 43	148 ± 60	< 0.001
Left atrial diameter, cm	4.7 ± 0.8	4.6 ± 0.8	0.46
E/E′mean	12.0 ± 4.0	13.9 ± 5.6	0.026
ePCWP, mm Hg	17 ± 5	19 ± 7	0.026
IVRT, ms	86 [75; 104]	97 [75; 120]	0.122

Mean values ± SD or median values and interquartiles, unless stated otherwise. BNP, brain natriuretic peptide; CITP, carboxy-terminal telopeptide of collagen type-I; E/E'mean, maximum E-wave velocity measured by pulsed wave Doppler/tissue Doppler imaging; ePCWP, estimated pulmonary capillary wedge pressure; IVRT, isovolumic relaxation time; LV, left ventricular; PICP, carboxy-terminal propeptide of procollagen type I. Glomerular filtration rate was estimated by the MDRD formula.