Quantitative analysis of skeletal muscle mass in patients with rheumatic diseases under glucocorticoid therapy – Comparison among bioelectrical impedance analysis, computed tomography, and magnetic resonance imaging

Abstract

Objectives. To determine the availability of bioelectrical impedance analysis (BIA), computed tomography (CT), and magnetic resonance imaging (MRI) for measurement of skeletal muscle mass in patients with rheumatic diseases and quantitatively assess skeletal muscle loss after glucocorticoid (GC) treatment.

Methods. The data from 22 patients with rheumatic diseases were retrospectively obtained. The muscle mass of body segments was measured with a BIA device in terms of skeletal muscle mass index (SMI). Cross-sectional area (CSA) was obtained from CT and MRI scans at the mid-thigh level using the image analysis program. We further assessed the data of three different measurements before and after GC treatment in 7 patients with rheumatic diseases.

Results. SMI of whole body was significantly correlated with estimated muscle volume and mid-thigh muscle CSA with CT and MRI (p < 0.01). Significant correlations between SMI and mid-thigh muscle CSA of each leg were also found (p < 0.01). All the three measurements were negatively correlated with GC dosage (p < 0.01). Significant decline in mid-thigh muscle CSA with CT and MRI was found after GC treatment in 7 patients (p < 0.02). Those patients showed significant decline in SMI of whole body after GC treatment, but not in SMI of each leg. On the other hand, significant correlations between mid-thigh muscle CSA with CT and MRI were found before and after GC treatment (p < 0.01).

Conclusions. GC-related skeletal muscle loss could be quantitatively assessed with BIA, CT, or MRI in patients with rheumatic diseases, and CT and MRI appeared to be more accurate than BIA.

Keywords:

• Bioelectrical impedance analysis
• Computed tomography
• Glucocorticoid
• Magnetic resonance imaging
• Muscle atrophy

Acknowledgements

The authors wish to thank Ms. Tomoka Uchiyama (TANITA Body Weight Scientific Institute) for technical advice and Ms. Tomoe Masuda for her clerical works. This work was supported by Grants-in-Aid for Scientific Research (KAKENHI) from the Japan Society for the Promotion of Science (JSPS) (H.T., N.S., N.Y., H.K. and O.H.), and by a grant-in-aid from the Ministry of Health, Labor and Welfare, Japan (H.T.).

Conflict of interest

None.