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Human Fertility
an international, multidisciplinary journal dedicated to furthering research and promoting good practice
Volume 14, 2011 - Issue 1
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Contraception

Phytochemical evaluation and antispermatogenic activity of Thevetia peruviana methanol extract in male albino rats

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Pages 53-59 | Published online: 05 Apr 2011
 

Abstract

This study was conducted to evaluate the antifertility potential of Thevetia peruviana (Apocynaceae) in male albino rats with their phytochemical evaluations. Phytochemical examination showed that plant is rich in active constituents, i.e. α-amyrin acetate, lupeol acetate, α-amyrin, β-amyrin, lupeol and thevetigenin. T. peruviana stem bark methanol extract (TPMtE) administered orally to male rats at the dose level of 100 mg/rat/day did not cause any significant reduction in body weight, while the weight of reproductive organs reduced significantly. A significant fall in the total protein and sialic acid content of the testes, epididymides, seminal vesicle and ventral prostate, as well as in the glycogen content of testes was also observed; however, cholesterol was increased significantly. TPMtE also caused a decline in spermatogenic elements, i.e. preleptotene and pachytene spermatocytes, secondary spermatocytes, round spermatids and mature Leydig cells. At this dose level Leydig cell nuclear diameter, seminiferous tubular diameter and Sertoli area were significantly reduced (p < 0.001). The reduction in sperm density and motility resulted in 18% residual fertility. In conclusion, T. peruviana inhibited spermatogenesis in rats, indicating the possibility of developing a herbal male contraceptive.

Acknowledgements

The investigation was supported by UGC regional office, Bhopal (MP). The authors are also thankful to the Head and Coordinator (CAS), Department of Zoology, Head, Department of Chemistry, University of Rajasthan, Jaipur (India) for providing necessary facilities.

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