Antioxidant effect of functionalized alkyl-organotellurides: a study in vitro

Figures & data

Scheme 1.  Chemical structures of functionalized alkyl-organotellurides A, B, C, and D.

Figure 1.  Effect of A (0.1–5 µM) (a), B (0.1–1 µM) (b), C (0.001– 1µM) (c), and D (0.1–1 µM) (d) on lipid peroxidation induced with Fe²⁺/EDTA. Data are reported as mean ± SD for four independent experiments, each one in duplicate. *, Denotes p < 0.05 as compared to the sample with Fe²⁺/EDTA (one-way ANOVA/Duncan). #, Denotes p < 0.05 as compared to control values (without Fe²⁺/EDTA and compounds) (one-way ANOVA/Duncan).

Table 1.  Calculated IC₅₀ values (µM) for lipid peroxidation and protein carbonyl content of functionalized alkyl-organotellurides in rat liver.

Compound	Lipid peroxidation		Protein carbonyl
	Fe^2+/EDTA	SNP	SNP
Vitamin E	2.47 (0.54–4.17)	2.97 (0.49–4.97)	326.34 (288.48–369.53)
Trolox	22.96 (19.92–26.45)	27.20 (18.76–39.55)	65.95 (60.67–71.70)
A	2.90 (2.60–3.20)	1.21 (1.05–1.40)	0.81 (0.72–0.92)
B	0.40 (0.37–0.44)	0.21 (0.19–0.22)	0.69 (0.47–1.02)
C	0.30 (0.24–0.54)	0.33 (0.12–0.89)	0.71 (0.58–0.89)
D	0.68 (0.65–0.71)	0.43 (0.36–0.51)	0.83 (0.70–0.98)

Note. 95% Confidence limit (µM) presented in parentheses.

Figure 2.  Effect of A (0.1–1 µM) (a), B (0.01–1 µM) (b), C (0.001–1 µM) (c), and D (0.1–1 µM) (d) on lipid peroxidation induced with SNP. Data are reported as mean ± SD for four independent experiments, each one in duplicate. *, Denotes p < 0.05 as compared to sample with SNP (one-way ANOVA/Duncan). #, Denotes p < 0.05 as compared to control values (without SNP and compounds) (one-way ANOVA/Duncan).

Figure 3.  Effect of A (0.1–1 µM) (a), B (0.1–1 µM) (b), C (0.001–1 µM) (c), and D (0.1–1 µM) (d) on protein carbonyl content. Data are reported as mean ± SD for four independent experiments, each one in duplicate. *, Denotes p < 0.05 as compared to the sample with SNP (one-way ANOVA/Duncan). #, Denotes p < 0.05 as compared to control values (without SNP and compounds) (one-way ANOVA/Duncan).

Figure 4.  Correlation between thiol oxidase property and δ-ALA-D activity of alkyl-organotelluride A.