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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 25, 2010 - Issue 4
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Original Article

Template synthesis, spectroscopic, antibacterial, and antifungal studies of trivalent transition metal ion macrocyclic complexes

D. P. SinghDepartment of Chemistry, National Institute of Technology, Kurukshetra, IndiaCorrespondence[email protected]
,
Krishan KumarDepartment of Chemistry, National Institute of Technology, Kurukshetra, India
,
Chetan SharmaDepartment of Microbiology, Kurukshetra University, Kurukshetra, India
&
K. R. AnejaDepartment of Microbiology, Kurukshetra University, Kurukshetra, India
Pages 544-550 | Received 28 Jul 2009, Accepted 22 Sep 2009, Published online: 17 Mar 2010

Figures & data

Table 1.  Analytical data of trivalent chromium, manganese, and iron complexes derived from 1,8-diaminonaphthalene and isatin.

Table 2.  FAB mass spectral data of the trivalent chromium, manganese, and iron complexes derived from 1,8-diaminonaphthalene and isatin.

Table 3.  In vitro antibacterial activity of synthesized macrocyclic complexes through agar well diffusion method.

Table 4.  Minimum inhibitory concentration (MIC) (in μg/mL) of synthesized macrocyclic complexes by using macrodilution method.

Table 5.  Minimum bactericidal concentration (MBC) (in µg/mL) of synthesized macrocyclic complexes by using macrodilution method.

Figure 1.  Comparison of MIC (μg/mL) of the synthesized macrocyclic complexes with standard antibiotic. a, Staphylococcus aureus (MTCC 96); b, Bacillus subtilis (MTCC 121); c, Escherichia coli (MTCC 1652); d, Pseudomonas aeruginosa (MTCC 741). Ciprofloxacin, standard antibiotic.

Figure 1.  Comparison of MIC (μg/mL) of the synthesized macrocyclic complexes with standard antibiotic. a, Staphylococcus aureus (MTCC 96); b, Bacillus subtilis (MTCC 121); c, Escherichia coli (MTCC 1652); d, Pseudomonas aeruginosa (MTCC 741). Ciprofloxacin, standard antibiotic.

Table 6.  In vitro antifungal activities of synthesized complexes through poisoned food method.

Figure 2.  Comparison of the (%) mycelial growth inhibition of complexes with standard antifungal drug amphotericin-B. e, Aspergillus niger (MTCC 282); f, Aspergillus flavus (MTCC 871). Amphotericin-B, standard drug.

Figure 2.  Comparison of the (%) mycelial growth inhibition of complexes with standard antifungal drug amphotericin-B. e, Aspergillus niger (MTCC 282); f, Aspergillus flavus (MTCC 871). Amphotericin-B, standard drug.

Figure 3.  Proposed structure of the synthesized macrocyclic complexes, where M = Cr(III), Mn(III), Fe(III); X = Cl−, NO3−, CH3COO− for Cr(III), Fe(III); X = CH3COO− for Mn(III).

Figure 3.  Proposed structure of the synthesized macrocyclic complexes, where M = Cr(III), Mn(III), Fe(III); X = Cl−, NO3−, CH3COO− for Cr(III), Fe(III); X = CH3COO− for Mn(III).

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