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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 25, 2010 - Issue 4
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Original Article

Design, synthesis, and urease inhibition studies of some 1,3,4-oxadiazoles and 1,2,4-triazoles derived from mandelic acid

Tashfeen AkhtarDepartment of Chemistry, Quaid-i-Azam University, Islamabad, Pakistan
,
Shahid HameedDepartment of Chemistry, Quaid-i-Azam University, Islamabad, PakistanCorrespondence[email protected]
,
Khalid M. KhanH. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
,
Ajmal KhanH. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
&
Muhammad Iqbal ChoudharyH. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan
Pages 572-576 | Received 13 Jul 2009, Accepted 06 Oct 2009, Published online: 17 Mar 2010

Figures & data

Scheme 1.  Synthesis of 1,3,4-oxadiazoles and 1,2,4-triazole-3-thiones. Reagents and conditions: (i) MeOH, reflux; (ii) Hg(OAc)2; (iii) 5% NaOH.

Scheme 1.  Synthesis of 1,3,4-oxadiazoles and 1,2,4-triazole-3-thiones. Reagents and conditions: (i) MeOH, reflux; (ii) Hg(OAc)2; (iii) 5% NaOH.

Table 1.  Urease inhibition studies of oxadiazoles (4a–e) and triazoles (5a–e).

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