Figures & data
Table 1. Summary of purification procedure for human carbonic anhydrase izoenzymes (hCA I and hCA II) by a sepharose-4B-aniline-sulphanilamide affinity column chromatography.
Table 2. The hCA I and II inhibition data with diazepam, midazolam and acetazolamideCitation8,Citation23, by an esterase assay with 4-nitrophenyl acetate as substrate.
Figure 1. The in vivo effects of diazepam and midazolam on rabbit erythrocytes CA activity. Five adult male New Zealand white rabbits (3–4.2 kg) were selected for intravenous administration of diazepam and midazolam (2 and 0.2 mg/kg body weight, respectively). Blood samples (10 × 0.5 ml) were taken from each rabbit prior to diazepam and midazolam administration as well as at 0.17, 0.5, 1, 2, 4, 6 and 24 h intervals thereafter.
