Inhibition of mammalian carbonic anhydrase isoforms I, II and VI with thiamine and thiamine-like molecules

Figures & data

Table 1.  K_I values obtained from regression analysis graphs for hCA I, hCA II and hCA VI in the presence of different inhibitors concentrations (µM).

Compound	hCA I	hCA II	hCA VI
1	2.27	0.784	0.593
2	1.15	0.105	0.128
3	0.38	0.085	0.062
EZA	0.03	0.011	0.050
ZNA	0.06	0.041	0.095
AZA	0.27	0.015	0.015

AZA, acetazolamide; EZA, sulfonamides ethoxzolamide; hCA, human erythrocyte carbonic anhydrase; ZNA, zonisamide.

Figure 1.  Structures of tested compounds and some clinical used sulfonamides.