Analysis of saponins and phenolic compounds as inhibitors of α-carbonic anhydrase isoenzymes

Figures & data

Figure 1.  Structures of the compounds 1–13 and AZA.

Table 1.  K_i values (μM) for compound 1–13 and AZA of some α-carbonic anhydrase isoforms in human (h) and bovine (b).

Compound	hCA I	hCA II	bCA III	hCA IV	hCA VI
1	2.68^a	2.54^a	3.73	7.89^a	6.17^a
2	1.73	0.83	4.77	3.76	7.82
3	2.42^a	1.84^a	9.71	4.90^a	4.91^a
4	2.32	1.24	8.93	3.98	4.36
5	0.97	0.113	2.21	1.12	1.49
6	1.49^b	2.51^b	5.68	8.96^b	9.70^b
7	0.94	0.47	1.38	2.41	4.71
8	1.47	0.97	1.93	2.75	6.96
9	1.98	1.13	2.18	3.94	7.37
10	2.21	1.28	2.49	4.36	9.78
11	10.2^c	5.5^c	4.63	9.5^c	208^c
12	4003^c	9.9^c	5.79	10.9^c	606^c
13	795^c	7.7^c	196	570^c	550^c
AZA	36.2	0.37	263	0.578	0.34

^aRef 47.

^bRef 48.

^cRef 49.