Synthesis and biological evaluation of some thiazole derivatives as new cholinesterase inhibitors

Gülhan Turan-ZitouniDepartment of Pharmaceutical Chemistry, Anadolu University, Faculty of Pharmacy, Eskişehir, Turkey

Ahmet OzdemirDepartment of Pharmaceutical Chemistry, Anadolu University, Faculty of Pharmacy, Eskişehir, Turkey

Zafer Asim KaplancikliDepartment of Pharmaceutical Chemistry, Anadolu University, Faculty of Pharmacy, Eskişehir, TurkeyCorrespondence[email protected]

Mehlika Dilek AltintopDepartment of Pharmaceutical Chemistry, Anadolu University, Faculty of Pharmacy, Eskişehir, Turkey

Halide Edip TemelDepartment of Biochemistry, Anadolu University, Faculty of Pharmacy, Eskişehir, Turkey

Gülşen Akalın ÇiftçiDepartment of Biochemistry, Anadolu University, Faculty of Pharmacy, Eskişehir, Turkey

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Table 1. Some properties of the synthesized compounds (4a–j).

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Scheme 1. The synthetic protocol of the title compounds (4a–j).

Table 2. The anticholinesterase activities of the compounds (4a–j) as IC₅₀ values (µg/mL).

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Table 3. In vitro cytotoxicity of the compounds (4a–j).

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Synthesis and biological evaluation of some thiazole derivatives as new cholinesterase inhibitors

Table 1. Some properties of the synthesized compounds (4a–j).

Table 2. The anticholinesterase activities of the compounds (4a–j) as IC₅₀ values (µg/mL).

Table 3. In vitro cytotoxicity of the compounds (4a–j).

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Synthesis and biological evaluation of some thiazole derivatives as new cholinesterase inhibitors

Figures & data

Table 1. Some properties of the synthesized compounds (4a–j).

Table 2. The anticholinesterase activities of the compounds (4a–j) as IC50 values (µg/mL).

Table 3. In vitro cytotoxicity of the compounds (4a–j).

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Table 2. The anticholinesterase activities of the compounds (4a–j) as IC₅₀ values (µg/mL).