Microwave-assisted synthesis of antimicrobial agents based on pyridazine moiety

Mansoura I. MohamedDepartment of Chemistry, Faculty of Women, Ain Shams University, Heliopolis 11757, Cairo, Egypt

Howida T. ZakyDepartment of Chemistry, Faculty of Women, Ain Shams University, Heliopolis 11757, Cairo, Egypt

Nadia G. KandileDepartment of Chemistry, Faculty of Women, Ain Shams University, Heliopolis 11757, Cairo, EgyptCorrespondence[email protected]

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Figure 1. Biologically active sulfonamide drugs.

Table 1. Sulfonamide derivatives (2a-p).

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Scheme 1. Synthesis of sulfonamide derivatives.

Scheme 2. (i) 3-Chloropyridazine derivatives/acetic acid/M.W. (ii) Benzaldehyde/acetic acid/M.W. (iii) Acetic acid derivatives/M.W. (iv) Thiosemicarbazide/acetic acid/M.W. (v) Succinic anhydride/toluene/M.W.

Scheme 3. A probable mechanistic pathway for the formation of the pyrrolin-2-one derivative (7).

Scheme 4. Synthesis of 3-[4-(2-methoxybenzyl)-6-(4-methoxyphenyl)pyridazin-3-yl-sulfonyl] oxazolidine-2-thione (8).

Table 2. Minimal inhibitory concentrations (MIC, μg/mL) and inhibition zones (mm) of the new synthesized compounds.

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Microwave-assisted synthesis of antimicrobial agents based on pyridazine moiety

Table 1. Sulfonamide derivatives (2a-p).

Table 2. Minimal inhibitory concentrations (MIC, μg/mL) and inhibition zones (mm) of the new synthesized compounds.

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Microwave-assisted synthesis of antimicrobial agents based on pyridazine moiety

Figures & data

Table 1. Sulfonamide derivatives (2a-p).

Table 2. Minimal inhibitory concentrations (MIC, μg/mL) and inhibition zones (mm) of the new synthesized compounds.

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