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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 30, 2015 - Issue 2
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Research Article

5-Membered cyclic hydroxamic acids as HDAC inhibitors

Ilze MutuleDepartment of Organic Chemistry, Latvian Institute of Organic Synthesis, Riga, Latvia
,
Diana BorovikaDepartment of Organic Chemistry, Latvian Institute of Organic Synthesis, Riga, Latvia
,
Elina RozenbergaDepartment of Organic Chemistry, Latvian Institute of Organic Synthesis, Riga, Latvia
,
Nadezhda RomanchikovaDepartment of Organic Chemistry, Latvian Institute of Organic Synthesis, Riga, Latvia
,
Raivis ZalubovskisDepartment of Organic Chemistry, Latvian Institute of Organic Synthesis, Riga, Latvia
,
Irina ShestakovaDepartment of Organic Chemistry, Latvian Institute of Organic Synthesis, Riga, Latvia
&
Peteris TrapencierisDepartment of Organic Chemistry, Latvian Institute of Organic Synthesis, Riga, LatviaCorrespondence[email protected]
 show all
Pages 216-223 | Received 13 Jan 2014, Accepted 29 Mar 2014, Published online: 18 Jun 2014

Figures & data

Scheme 1. Synthesis of 5-CHA 10 and 11.

Scheme 1. Synthesis of 5-CHA 10 and 11.

Scheme 2. Unsaturated aldehyde 8c–g synthesis.

Scheme 2. Unsaturated aldehyde 8c–g synthesis.

Table 1. IC50 values (µM) for the HDAC inhibitory activity of 5-CHA.

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