Dipotassium-trioxohydroxytetrafluorotriborate, K₂[B₃O₃F₄OH], is a potent inhibitor of human carbonic anhydrases

Daniela VulloPolo Scientifico, Laboratorio di Chimica Bioinorganica, Università degli Studi di Firenze, Sesto Fiorentino (Florence), Italy,

Mladen MilosDepartment of Biochemistry, Faculty of Chemistry and Technology, University of Split, Split, Croatia,

Borivoj GalicDepartment of Chemistry, Faculty of Science, University of Sarajevo, Sarajevo, Bosnia and Herzegovina, and

Andrea ScozzafavaPolo Scientifico, Laboratorio di Chimica Bioinorganica, Università degli Studi di Firenze, Sesto Fiorentino (Florence), Italy,

Claudiu T. SupuranNeurofarba Department, Section of Pharmaceutical and Nutriceutical Sciences, Università degli Studi di Firenze, Sesto Fiorentino (Florence), ItalyCorrespondence[email protected]

Figures & data

Figure 1. Structures of tetraborate (as [B₄O₅(OH)₄]²⁻ ion) (A); phenylboronic acid (B); trioxohydroxytetrafluorotriborate (C) and proposed binding of the last anion to the Zn(II) ion from the α-CA active site (D).

Figure 1. Structures of tetraborate (as [B4O5(OH)4]2− ion) (A); phenylboronic acid (B); trioxohydroxytetrafluorotriborate (C) and proposed binding of the last anion to the Zn(II) ion from the α-CA active site (D).

Table 1. Inhibition constants of boron-containing inhibitors against human α-CAs, for the CO₂ hydration reaction, at 20 °C, pH 7.5Citation40.

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Dipotassium-trioxohydroxytetrafluorotriborate, K₂[B₃O₃F₄OH], is a potent inhibitor of human carbonic anhydrases

Table 1. Inhibition constants of boron-containing inhibitors against human α-CAs, for the CO₂ hydration reaction, at 20 °C, pH 7.5Citation40.

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Dipotassium-trioxohydroxytetrafluorotriborate, K2[B3O3F4OH], is a potent inhibitor of human carbonic anhydrases

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Table 1. Inhibition constants of boron-containing inhibitors against human α-CAs, for the CO2 hydration reaction, at 20 °C, pH 7.5Citation40.

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Dipotassium-trioxohydroxytetrafluorotriborate, K₂[B₃O₃F₄OH], is a potent inhibitor of human carbonic anhydrases

Table 1. Inhibition constants of boron-containing inhibitors against human α-CAs, for the CO₂ hydration reaction, at 20 °C, pH 7.5Citation40.