7-Amino-3,4-dihydro-1H-quinolin-2-one, a compound similar to the substituted coumarins, inhibits α-carbonic anhydrases without hydrolysis of the lactam ring

Daniela VulloDepartment of Chemistry ”Ugo Shiff”, University of Florence, Sesto Fiorentino, Italy, Correspondence[email protected]

Semra IsikDepartment of Chemistry, Balikesir University, Balikesir, Turkey, and

Murat BozdagDepartment of Chemistry ”Ugo Shiff”, University of Florence, Sesto Fiorentino, Italy,

Fabrizio CartaDepartment of Chemistry ”Ugo Shiff”, University of Florence, Sesto Fiorentino, Italy,

Claudiu T. SupuranNEUROFARBA Department, University of Florence, Sesto Fiorentino, Italy

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Scheme 1. Tautomeric forms 1a and 1b of the investigated derivative 1.

Table 1. Human CA isoforms inhibition data with compounds 1, 2 and AAZ as standard, by a stopped-flow CO2 hydrase assayCitation49..

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7-Amino-3,4-dihydro-1H-quinolin-2-one, a compound similar to the substituted coumarins, inhibits α-carbonic anhydrases without hydrolysis of the lactam ring

Table 1. Human CA isoforms inhibition data with compounds 1, 2 and AAZ as standard, by a stopped-flow CO2 hydrase assayCitation49..

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7-Amino-3,4-dihydro-1H-quinolin-2-one, a compound similar to the substituted coumarins, inhibits α-carbonic anhydrases without hydrolysis of the lactam ring

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Table 1. Human CA isoforms inhibition data with compounds 1, 2 and AAZ as standard, by a stopped-flow CO2 hydrase assayCitation49..

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