Figure 1. Unifiram (DM232, 1) and Sunifiram (DM235, 2).
Scheme 1. Chemical modulation of Unifiram.
Scheme 2. Chemical modulation of Sunifiram.
Scheme 3. Further chemical modulation of Sunifiram.
Scheme 4. Effect on nootropic activity of benzoyl and 4-F-benzenesulfonyl groups on the scaffolds of Unifiram and Sunifiram.
Figure 2. ACh release from rat cerebral cortex induced by Sunifiram (2), Unifiram (1), (S)-(−)-1 and (R)-(+)-1 (0.01 mg/kg).
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