Pregnancy outcome in patients with fibromyalgia syndrome

Abstract

Objective. To investigate pregnancy outcome of patients with fibromyalgia syndrome (FMS).

Methods. A retrospective cohort study comparing pregnancies of women with and without FMS was conducted. Multivariable logistic regression models was performed to control for confounders

Results. Deliveries of 112 women with FMS were compared with a control group of 487 deliveries of women without FMS. Parturients with FMS had higher rates of intrauterine growth restriction (IUGR; 7.1% vs. 1.0%, p = 0.001), recurrent abortions (9.8% vs. 1.8%, p < 0.001), gestational diabetes mellitus (14.3% vs. 7%, p = 0.012), and polyhydramnios (12.5% vs. 1.6%, p < 0.001). These patients had lower rates of preterm deliveries (PTD; 6.3% vs. 16.7%, p = 0.018). No significant differences were noted between the groups regarding the rates of cesarean deliveries (CD) (15.2% vs. 21.2%, p =  0.149) and perinatal outcomes such as low Apgar scores (<7) at 1 and 5 min (4.5% vs. 6.7%, p = 0.292 and 1.2% vs. 0.6%, p = 0.372; respectively). Using two multiple logistic regression models, the positive association between FMS and IUGR (adjusted OR = 4.1, 95% CI 1.2–13.2; p = 0.02) and the negative association with PTD (OR = 0.3, 95% CI 0.2–0.6; p = 0.001) remained significant.

Conclusion. FMS is an independent risk factor for intrauterine growth restriction. Nevertheless, it is associated with lower rates of preterm deliveries.

Keywords:

• Intrauterine growth restriction (IUGR)
• preterm delivery (PTD)

Declaration of interest: The work is supported partly by a Grant from the Whitman family, Ben-Gurion University of the Negev, Center for Women's Health Studies and Promotion. The work is performed to partly fulfill the MD requirements of Tammy Zioni's.