Secreted phospholipase A₂ is increased in meconium-stained amniotic fluid of term gestations: potential implications for the genesis of meconium aspiration syndrome

Roberto RomeroPerinatology Research Branch, NICHD/NIH/DHHS Bethesda, MD and Detroit, MIUSA;Department of Obstetrics and Gynecology, University of Michigan Ann ArborMI;Department of Epidemiology and Biostatistics, Michigan State University East LansingMICorrespondence[email protected]

Bo Hyun YoonPerinatology Research Branch, NICHD/NIH/DHHS Bethesda, MD and Detroit, MIUSA;Department of Obstetrics and Gynecology, Seoul National University College of Medicine SeoulRepublic of Korea

Piya ChaemsaithongPerinatology Research Branch, NICHD/NIH/DHHS Bethesda, MD and Detroit, MIUSA;Department of Obstetrics and Gynecology, Wayne State University Detroit, MIUSA

Josef CortezPerinatology Research Branch, NICHD/NIH/DHHS Bethesda, MD and Detroit, MIUSA;Department of Pediatrics, Wayne State University Detroit, MIUSA

Chan-Wook ParkDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine SeoulRepublic of Korea

Rogelio GonzalezCenter for Perinatal Diagnosis and Research (CEDIP), Hospital Dr. Sotero del Rio, P. Universidad Catolica de Chile Puente AltoChile

Ernesto BehnkeDepartment of Obstetrics and Gynecology, Center for Perinatal Diagnosis and Research (CEDIP), Sotero del Rio Hospital SantiagoChile

Sonia S. HassanPerinatology Research Branch, NICHD/NIH/DHHS Bethesda, MD and Detroit, MIUSA;Department of Obstetrics and Gynecology, Wayne State University Detroit, MIUSA

Francesca GotschPerinatology Research Branch, NICHD/NIH/DHHS Bethesda, MD and Detroit, MIUSA;Azienda Ospedaliera Universitaria, Integrata Verona, Ostetricia Ginecologia VeronaItaly

Lami YeoPerinatology Research Branch, NICHD/NIH/DHHS Bethesda, MD and Detroit, MIUSA;Department of Obstetrics and Gynecology, Wayne State University Detroit, MIUSA

Tinnakorn ChaiworapongsaPerinatology Research Branch, NICHD/NIH/DHHS Bethesda, MD and Detroit, MIUSA;Department of Obstetrics and Gynecology, Wayne State University Detroit, MIUSA

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Figures & data

Figure 1. Amniotic fluid secreted phospholipase A₂ concentrations (sPLA₂) in women at term with clear amniotic fluid and MSAF. Patients with MSAF had a significantly higher median amniotic fluid secreted phospholipase A₂ concentration (ng/mL) than those with clear amniotic fluid [1.7 (1–2.9) versus 0.3 (0–0.6); p < 0.001].

Figure 1. Amniotic fluid secreted phospholipase A2 concentrations (sPLA2) in women at term with clear amniotic fluid and MSAF. Patients with MSAF had a significantly higher median amniotic fluid secreted phospholipase A2 concentration (ng/mL) than those with clear amniotic fluid [1.7 (1–2.9) versus 0.3 (0–0.6); p < 0.001].

Figure 2. Amniotic fluid secreted phospholipase A₂ concentration (sPLA₂) among women with MSAF at term with presence and absence of endotoxin or microorganisms. Patients with MSAF and intra-amniotic inflammation/infection at term had a significantly higher median secreted phospholipase A₂ concentration (ng/mL) than those without intra-amniotic inflammation/infection [2.4 (1.7–6.99) versus 1.7 (1.3–2.5); p = 0.049].

Figure 2. Amniotic fluid secreted phospholipase A2 concentration (sPLA2) among women with MSAF at term with presence and absence of endotoxin or microorganisms. Patients with MSAF and intra-amniotic inflammation/infection at term had a significantly higher median secreted phospholipase A2 concentration (ng/mL) than those without intra-amniotic inflammation/infection [2.4 (1.7–6.99) versus 1.7 (1.3–2.5); p = 0.049].

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Secreted phospholipase A₂ is increased in meconium-stained amniotic fluid of term gestations: potential implications for the genesis of meconium aspiration syndrome

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Secreted phospholipase A₂ is increased in meconium-stained amniotic fluid of term gestations: potential implications for the genesis of meconium aspiration syndrome