A rapid interleukin-6 bedside test for the identification of intra-amniotic inflammation in preterm labor with intact membranes

Piya ChaemsaithongDivision of Intramural Research, Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD and Detroit, MI, USA, ;Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA,

Roberto RomeroDivision of Intramural Research, Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD and Detroit, MI, USA, ;Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA, ;Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA, and Correspondence[email protected]

Steven J. KorzeniewskiDivision of Intramural Research, Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD and Detroit, MI, USA, ;Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA, ;Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA, and

Alicia Martinez-VareaDivision of Intramural Research, Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD and Detroit, MI, USA, ;Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA,

Zhong DongDivision of Intramural Research, Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD and Detroit, MI, USA, ;Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA,

Bo Hyun YoonDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea

Sonia S. HassanDivision of Intramural Research, Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD and Detroit, MI, USA, ;Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA,

Tinnakorn ChaiworapongsaDivision of Intramural Research, Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD and Detroit, MI, USA, ;Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA,

Lami YeoDivision of Intramural Research, Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD and Detroit, MI, USA, ;Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA,

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Table 1. Clinical characteristics of the study population.

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Table 2. Clinical characteristics, amniotic fluid inflammatory response and acute inflammatory placental lesions in patients with microbial invasion of the amniotic cavity using cultivation techniques.

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Figure 1. Receiver operating characteristic curve that describes the performance of point of care test amniotic fluid interleukin-6 in the identification of intra-amniotic inflammation (determined by ELISA IL-6 ≥ 2600 pg/mL) (area under the curve for amniotic fluid IL-6 point of care test = 0.94; 95% confidence interval: 0.90–0.99, p < 0.001).

Table 3. Diagnostic performance of point of care AF IL-6 concentrations and ELISA AF IL-6 for identification of intra-amniotic infection and/or inflammation and placental lesions consistent with acute inflammation.

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Table 4. Diagnostic performance of point of care AF IL-6 concentrations and ELISA AF IL-6 for identification of patients with spontaneous preterm delivery.

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A rapid interleukin-6 bedside test for the identification of intra-amniotic inflammation in preterm labor with intact membranes

Table 1. Clinical characteristics of the study population.

Table 2. Clinical characteristics, amniotic fluid inflammatory response and acute inflammatory placental lesions in patients with microbial invasion of the amniotic cavity using cultivation techniques.

Table 3. Diagnostic performance of point of care AF IL-6 concentrations and ELISA AF IL-6 for identification of intra-amniotic infection and/or inflammation and placental lesions consistent with acute inflammation.

Table 4. Diagnostic performance of point of care AF IL-6 concentrations and ELISA AF IL-6 for identification of patients with spontaneous preterm delivery.

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A rapid interleukin-6 bedside test for the identification of intra-amniotic inflammation in preterm labor with intact membranes

Figures & data

Table 1. Clinical characteristics of the study population.

Table 2. Clinical characteristics, amniotic fluid inflammatory response and acute inflammatory placental lesions in patients with microbial invasion of the amniotic cavity using cultivation techniques.

Table 3. Diagnostic performance of point of care AF IL-6 concentrations and ELISA AF IL-6 for identification of intra-amniotic infection and/or inflammation and placental lesions consistent with acute inflammation.

Table 4. Diagnostic performance of point of care AF IL-6 concentrations and ELISA AF IL-6 for identification of patients with spontaneous preterm delivery.

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