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Original Article

A point of care test for interleukin-6 in amniotic fluid in preterm prelabor rupture of membranes: a step toward the early treatment of acute intra-amniotic inflammation/infection

Piya ChaemsaithongDivision of Intramural Research, Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Detroit, MI, USA, ;Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA,

Roberto RomeroDivision of Intramural Research, Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Detroit, MI, USA, ;Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA, ;Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA, and Correspondence[email protected]

Steven J. KorzeniewskiDivision of Intramural Research, Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Detroit, MI, USA, ;Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA, ;Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA, and

Alicia Martinez-VareaDivision of Intramural Research, Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Detroit, MI, USA, ;Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA,

Zhong DongDivision of Intramural Research, Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Detroit, MI, USA, ;Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA,

Bo Hyun YoonDepartment of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea

Sonia S. HassanDivision of Intramural Research, Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Detroit, MI, USA, ;Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA,

Tinnakorn ChaiworapongsaDivision of Intramural Research, Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Detroit, MI, USA, ;Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA,

Lami YeoDivision of Intramural Research, Perinatology Research Branch, Program for Perinatal Research and Obstetrics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Detroit, MI, USA, ;Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, USA,

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Figures & data

Table 1. Clinical characteristics of the study population.

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Table 2. Clinical characteristics, amniotic fluid inflammatory response and acute inflammatory placental lesions in patients with microbial invasion of the amniotic cavity using cultivation techniques.

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Table 3. Diagnostic performance of point of care AF IL-6 concentrations and ELISA AF IL-6 for identification of intra-amniotic inflammation, intra-amniotic infection and placental lesions consistent with acute inflammation.

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Table 4. Pregnancy outcomes according to the results of point of care IL-6 (using cut-off: 745 pg/ml).

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A point of care test for interleukin-6 in amniotic fluid in preterm prelabor rupture of membranes: a step toward the early treatment of acute intra-amniotic inflammation/infection

Table 1. Clinical characteristics of the study population.

Table 2. Clinical characteristics, amniotic fluid inflammatory response and acute inflammatory placental lesions in patients with microbial invasion of the amniotic cavity using cultivation techniques.

Table 3. Diagnostic performance of point of care AF IL-6 concentrations and ELISA AF IL-6 for identification of intra-amniotic inflammation, intra-amniotic infection and placental lesions consistent with acute inflammation.

Table 4. Pregnancy outcomes according to the results of point of care IL-6 (using cut-off: 745 pg/ml).

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A point of care test for interleukin-6 in amniotic fluid in preterm prelabor rupture of membranes: a step toward the early treatment of acute intra-amniotic inflammation/infection

Figures & data

Table 1. Clinical characteristics of the study population.

Table 2. Clinical characteristics, amniotic fluid inflammatory response and acute inflammatory placental lesions in patients with microbial invasion of the amniotic cavity using cultivation techniques.

Table 3. Diagnostic performance of point of care AF IL-6 concentrations and ELISA AF IL-6 for identification of intra-amniotic inflammation, intra-amniotic infection and placental lesions consistent with acute inflammation.

Table 4. Pregnancy outcomes according to the results of point of care IL-6 (using cut-off: 745 pg/ml).

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