Responsiveness of Three Instruments to Assess Self-Reported Functional Status in Patients with COPD

Figures & data

Table 1  Characterization of the 22 patients with COPD included in the study

Age (years)	66 ± 07
Gender (M/F)	11/11
BMI (kg/m^2)	27 ± 6
Literate (Yes/No)	17/5
FEV1 (% pred)	43 ± 14
FVC (% pred)	68 ± 17
FEV1/FVC	50±14
GOLD (I/II/III/IV)	0/8/10/4
6MWT (m)	445 ± 81
6MWT (% pred)	76 ± 11

Data described as mean ± standard deviation. M = male; F = female; BMI = body mass index; FEV₁ = forced expiratory volume in the first second; FVC = forced vital capacity; GOLD = Global Initiative for Chronic Obstructive Lung Disease; 6MWT = 6 minute walking test.

Table 2  Comparison between the different domains of PFSDQ-M, LCADL, MRC scale and SGRQ questionnaires, for the responsiveness analysis after a 3-month high intensity exercise training program in patients with COPD

Questionnaire	Domains	Before Treatment	After Treatment	p-value
PFSDQ-M	Dyspnea	16[10–40]	10[4–32]	0.07
	Fatigue	18[9–34]	13[4–29]	0.27
	Change in ADL	29[13–37]	19[4–40]	0.04
LCADL	Self-Care	6[5–9]	4[4–6]	0.001
	Domestic	8[4–9]	5[3–9]	0.005
	Physical Activity	4[3–5]	3[3–4]	0.10
	Leisure	4[4–6]	3[3–5]	0.001
	Total	20[16–28]	17[14–23]	0.0004
MRC		3[2–4]	2[2–4]	0.11
SGRQ	Symptoms	59[34–72]	43[28–59]	0.049
	Physical Activity	66[48–84]	51[23–64]	0.0009
	Impact	42[29–89]	24[10–41]	0.0008
	Total	53[41–65]	34[24–49]	0.0003

Data are described as median [interquartile range].

PFSDQ-M = Modified Pulmonary Functional Status and Dyspnea Questionnaire; ADL = activities of daily living; LCADL = London Chest Activity of Daily Living Scale; MRC = Medical Research Council scale; SGRQ = Saint George Respiratory Questionnaire.

Table 3  Comparison between the different domains of PFSDQ-M, LCADL and MRC scale concerning different aspects of the responsiveness analysis after a high intensity exercise program (n = 22)

	Effect Size	Standardized Response Mean	Standard Error of Measurement
PFSDQ-M
Dyspnea	0.26	0.43	2.82
Fatigue	0.16	0.27	3.15
Change in ADL	0.33	0.48	3.19
LCADL
Self-care	0.60	0.75	0.40
Domestic	0.26	0.73	0.50
Physical Activity	0.43	0.40	0.24
Leisure	0.61	0.81	0.21
Total	0.45	0.91	1.03
MRC	0.36	0.39	0.22

PFSDQ-M = Modified Pulmonary Functional Status and Dyspnea Questionnaire; ADL = activities of daily living; LCADL = London Chest Activity of Daily Living Scale; MRC = Medical T Council scale.