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ORIGINAL RESEARCH

Spirometric Thresholds for Diagnosing COPD: 0.70 or LLN, Pre- or Post-dilator Values?

Firdaus A. A. Mohamed HoeseinDivision of Heart & Lungs, Department of Respiratory Medicine, University Medical Center Utrecht, Utrecht, the NetherlandsCorrespondence[email protected]

Pieter ZanenDivision of Heart & Lungs, Department of Respiratory Medicine, University Medical Center Utrecht, Utrecht, the Netherlands

Alfred P. E. SachsJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands

Theo J. M. VerheijJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands

Jan-Willem J. LammersDivision of Heart & Lungs, Department of Respiratory Medicine, University Medical Center Utrecht, Utrecht, the Netherlands

Berna D. L. BroekhuizenJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands

Figures & data

Figure 1. Flow chart of inclusion criteria and number of participants included.

Table 1. Participants demographics and results from the pulmonary function tests stratified the panel diagnosis

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Table 2. Positive and negative predictive values of FEV1/FVC <0.70 and <LLN for COPD, (post-bronchodilator values)

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Table 3. Number (percentage) of correct and wrong diagnoses of COPD according to FEV1/FVC <0.70 and <LLN (post-bronchodilator values)

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Figure 2. Receiver operating curve (ROC) for pre- and post-bronchodilator FEV1/FVC values in diagnosing COPD.

Figure 3. Receiver operating curve (ROC) for pre- and post-bronchodilator FEV1 [L] values in diagnosing COPD.

Table 4. Number of participants changing from below the thresholds to above the thresholds or vice versa after the administration of a bronchodilator according to FEV1/FVC <0.70 and <LLN

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Spirometric Thresholds for Diagnosing COPD: 0.70 or LLN, Pre- or Post-dilator Values?

Table 1. Participants demographics and results from the pulmonary function tests stratified the panel diagnosis

Table 2. Positive and negative predictive values of FEV1/FVC <0.70 and <LLN for COPD, (post-bronchodilator values)

Table 3. Number (percentage) of correct and wrong diagnoses of COPD according to FEV1/FVC <0.70 and <LLN (post-bronchodilator values)

Table 4. Number of participants changing from below the thresholds to above the thresholds or vice versa after the administration of a bronchodilator according to FEV1/FVC <0.70 and <LLN

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Spirometric Thresholds for Diagnosing COPD: 0.70 or LLN, Pre- or Post-dilator Values?

Figures & data

Table 1. Participants demographics and results from the pulmonary function tests stratified the panel diagnosis

Table 2. Positive and negative predictive values of FEV1/FVC <0.70 and <LLN for COPD, (post-bronchodilator values)

Table 3. Number (percentage) of correct and wrong diagnoses of COPD according to FEV1/FVC <0.70 and <LLN (post-bronchodilator values)

Table 4. Number of participants changing from below the thresholds to above the thresholds or vice versa after the administration of a bronchodilator according to FEV1/FVC <0.70 and <LLN

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