980
Views
17
CrossRef citations to date
0
Altmetric
Research Article

Bisphenol A at concentrations relevant to human exposure enhances histamine and cysteinyl leukotriene release from bone marrow-derived mast cells

, &
Pages 84-89 | Received 07 Mar 2013, Accepted 26 Apr 2013, Published online: 19 Jun 2013

Figures & data

Figure 1. (a) Percentage increase in histamine release from BMMC following 30-min treatment with E2 (open bars) (n = 6) or BPA (solid bars) (n = 6). (b) CysLT release following 30-min treatment with BPA (n = 4). Bars represent mean ± SEM. *p < 0.05 and **p ≤ 0.001 compared to untreated cells.

Figure 1. (a) Percentage increase in histamine release from BMMC following 30-min treatment with E2 (open bars) (n = 6) or BPA (solid bars) (n = 6). (b) CysLT release following 30-min treatment with BPA (n = 4). Bars represent mean ± SEM. *p < 0.05 and **p ≤ 0.001 compared to untreated cells.

Figure 2. (a) Percentage increase in histamine release from BMMC pre-treated with ICI for 1 h before treatment with 10 nM E2 (open bars) (n = 3) or 10 nM BPA (solid bars) (n = 3) for 30 min. (b) CysLT release from BMMC pre-treated with (shaded bar) or without (solid bar) 1 μM ICI before treatment with 10 nM BPA (n = 4). Bars represent mean ± SEM. *p < 0.05 compared to no ICI treatment. p < 0.05 compared to control.

Figure 2. (a) Percentage increase in histamine release from BMMC pre-treated with ICI for 1 h before treatment with 10 nM E2 (open bars) (n = 3) or 10 nM BPA (solid bars) (n = 3) for 30 min. (b) CysLT release from BMMC pre-treated with (shaded bar) or without (solid bar) 1 μM ICI before treatment with 10 nM BPA (n = 4). Bars represent mean ± SEM. *p < 0.05 compared to no ICI treatment. †p < 0.05 compared to control.

Figure 3. Percentage increase in (a) histamine release and (b) CysLT release from BMMC pre-treated with 10 μM U0126 (shaded bar) or 3 mM EGTA (checkered bar) for 1 h before treatment with 10 nM BPA for 30 min. Bars represent mean ± SEM. n = 3 for all experiments. *p < 0.05, **p < 0.005, and ***p < 0.001.

Figure 3. Percentage increase in (a) histamine release and (b) CysLT release from BMMC pre-treated with 10 μM U0126 (shaded bar) or 3 mM EGTA (checkered bar) for 1 h before treatment with 10 nM BPA for 30 min. Bars represent mean ± SEM. n = 3 for all experiments. *p < 0.05, **p < 0.005, and ***p < 0.001.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.