Figures & data
Figure 1. Levels of (a) CysLT and (b) PGD2 secreted after IgE cross-linking from BMMC of animals exposed perinatally to BPA. Concentrations of CysLT and PGD2 were determined from cell culture supernatants collected after 30 min of cellular activation. Bars represent mean (±SEM) for n = 3–5 mice per group. *p < 0.05 and **p < 0.01 compared to control.
Figure 2. Levels of (a) TNFα, (b) IL-13, (c) IL-4, (d) IL-5, and (e) IL-6 secreted after IgE cross-linking from BMMC of animals exposed perinatally to BPA. Concentrations of TNFα, IL-13, IL-4, IL-5, and IL-6 were determined from cell culture supernatants collected after 30 min of cellular activation. Bars represent mean (±SEM) for n = 3–5 mice per group. *p < 0.05 and **p < 0.01 compared to control.
Figure 3. Percentage of histamine release secreted after IgE cross-linking from BMMC of animals exposed perinatally to BPA, as compared to IgE-free control. Relative fluorescence units were determined from cell culture supernatants collected after 30 min of cellular activation. Bars represent mean (±SEM) for n = 3–5 mice per group.
Figure 4. Decreased levels of global DNA methylation in BMMC from adult animals which had perinatal BPA exposure. DNA was isolated from cultured BMMC of adult animals, and 5-mC concentration was measured. Bars represent mean arbitrary OD units (±SEM) for n = 3–5 mice per group. *p < 0.05 compared to control.
