Figures & data
Figure 1. Representative liver section light microscopy photographs. Sections of livers from control (a) and LF treated (b–f) adult rats. Thick arrowhead: smaller cells with eosinophilic cytoplasm and damaged nuclei; asterisk: dilated sinusoid; thick arrow: giant hepatocytes; waved arrows: peri-nuclear and cytoplasmic vacuoles; double asterisks: cellular debris; K: Kupffer cell; thin arrowhead: thinned hepatocyte cords. Eosinophilic-dyed infiltrates can be seen in (e); (a) shows a portal area structure in livers of control rats. Scale = 50 µm.
Figure 2. Representative liver section electron microscopy photographs. (a–d) Samples from control rats. n, hepatocyte nucleus; m, mitochondria; er, smooth endoplasmic reticulum; ger, rough endoplasmic reticulum; lz, lysosome; s, bile canalicule; gl, glycogen; j, junctional complex; He, hepatocytes; E, endothelial cell; si, sinusoid; er, erythrocyte; K, Kupffer cell; asterisk shows space of Disse. (e–g) Samples from LF-treated rats. L, lipid droplet; v, vacuole; n, hepatocyte nucleus; E, pycnotic endothelial cell nuclei; er, erythrocyte; sl, secondary lysosome in Kupffer cell; He, hepatocytes; m, mitochondria; black arrow: flattened hepatocyte microvilli; white arrow: electron-dense material in space of Disse similar to cytoplasmic particles containing cellular debris; black arrowheads: myelin-like membranes of primary lysosomes; asterisk shows enlarged distance between cells, including bile canalicule. Scale = 0.5 µm.
Figure 3. Representative liver section electron microscopy photographs (a–f). Samples from LF rats. L, lipid droplet; m, mitochondria; ger, rough endoplasmic reticulum; gl, glycogen deposits; st, cytoplasm; He, hepatocyte; E, endothelial cell; si, sinusoid; arrow: dilated smooth endoplasmic reticulum; er, erythrocyte; mf, myofibroblast; f, fibrin deposition, t, thrombocyte; black arrow, perisinusoidal localization of connective tissue fibers; asterisk: expanded space of Disse; n, nucleus. Scale = 0.5 µm.
