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CLINICOPATHOLOGIC CASE

Twin Infant with Lymphatic Dysplasia Diagnosed with Noonan Syndrome by Molecular Genetic Testing

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Pages 253-257 | Received 04 Mar 2014, Accepted 10 Mar 2014, Published online: 22 Apr 2014

Figures & data

Figure 1. Composite photograph with gross and photomicrographs from the autopsy. A. The lungs after 24 h of formalin fixation. When fresh, they were pale pink with a slightly bumpy pleural surface. The aorta is horizontally placed at the upper portion of the photograph. B. Hematoxylin-and eosin (H&E)-stained photograph taken from the lung with the 4× -lens depicts the pleural surface and part of the pulmonary parenchyma. Notice the dilated vessels. C. Same field of view and magnification as in 1-B, but stained by immunohistochemistry for D2-40 highlights the lymphatic origin of dilated vessels. D. The upper part of the abdominal organs demonstrates the liver with gallbladder, intestine and congested mesenteric vessels. E. The H&E-stained photomicrograph from intestine and mesentery with the 4× -lens shows the intestine in the right lower corner and numerous dilated mesenteric vessels. F. Same field of view and magnification as in 1-E, but stained by immunohistochemistry for D2-40 highlights the lymphatic nature of dilated vessels.

Figure 1.  Composite photograph with gross and photomicrographs from the autopsy. A. The lungs after 24 h of formalin fixation. When fresh, they were pale pink with a slightly bumpy pleural surface. The aorta is horizontally placed at the upper portion of the photograph. B. Hematoxylin-and eosin (H&E)-stained photograph taken from the lung with the 4× -lens depicts the pleural surface and part of the pulmonary parenchyma. Notice the dilated vessels. C. Same field of view and magnification as in 1-B, but stained by immunohistochemistry for D2-40 highlights the lymphatic origin of dilated vessels. D. The upper part of the abdominal organs demonstrates the liver with gallbladder, intestine and congested mesenteric vessels. E. The H&E-stained photomicrograph from intestine and mesentery with the 4× -lens shows the intestine in the right lower corner and numerous dilated mesenteric vessels. F. Same field of view and magnification as in 1-E, but stained by immunohistochemistry for D2-40 highlights the lymphatic nature of dilated vessels.