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Clinical Toxicology Volume 50, 2012 - Issue 5
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Research Article

Postpartum maternal codeine therapy and the risk of adverse neonatal outcomes: A retrospective cohort study

David N. JuurlinkInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada;Department of Medicine, University of Toronto, Toronto, ON, Canada;Hospital for Sick Children and Department of Pediatrics, University of Toronto, Toronto, ON, Canada;Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada;The Sunnybrook Research Institute, Toronto, ON, CanadaCorrespondence[email protected]
,
Tara GomesInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada;The Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada
,
Astrid GuttmannInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada;Hospital for Sick Children and Department of Pediatrics, University of Toronto, Toronto, ON, Canada;Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada
,
Chelsea HellingsInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada
,
Marco L. A. SivilottiDepartments of Emergency Medicine, and Pharmacology & Toxicology, Queen's University, Kingston, ON, Canada
,
Marie-Andrée HarveyDepartments of Obstetrics & Gynaecology and of Urology, Queen's University, Kingston, ON, Canada
&
Muhammad M. MamdaniInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada;The Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada;Department of Medicine, University of Toronto, Toronto, ON, Canada;Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada;Department of Medicine, St. Michael's Hospital, Toronto, ON, Canada;Keenan Research Centre of the Li Ka-Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada;College of Medicine, King Saud University, Riyadh, Saudi Arabia
 show all
Pages 390-395 | Received 12 Mar 2011, Accepted 26 Mar 2012, Published online: 27 Apr 2012

Figures & data

Table 1. Characteristics of study subjects.

Fig. 1. Kaplan–Meier curves for all-cause hospital readmission among neonates, by maternal codeine prescription. Cumulative proportion of neonates readmitted to hospital for any reason within 30 days of the date of issue for the maternal codeine prescription among exposed neonates (solid line) and the corresponding date among unexposed infants (dashed line).

Fig. 1. Kaplan–Meier curves for all-cause hospital readmission among neonates, by maternal codeine prescription. Cumulative proportion of neonates readmitted to hospital for any reason within 30 days of the date of issue for the maternal codeine prescription among exposed neonates (solid line) and the corresponding date among unexposed infants (dashed line).

Table 2. Association between maternal medication use and neonatal readmission to hospital for any reason.

Table 3. Association between maternal codeine exposure and secondary neonatal outcomes.

Supplemental material

http://www.informahealthcare.com/doi/abs/10.3109/15563650.2012.681052

Download PDF (124.6 KB)

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