The changes in hazard classification and product notification procedures of the new European CLP and Cosmetics Regulations

Figures & data

Fig. 1. Health hazard classification of substances and mixtures according to the CLP Regulation (EC) No 1272/2008 (entered into force from January 20, 2009) compared with the classification according to Directive 67/548/EEC.^1,7

Fig. 2. Comparison between the new CLP Regulation (EC) No 1272/2008 (entered into force from January 20, 2009) pictograms and the old Directive 67/548/EEC pictograms for health hazards. Risk (R)-phrases and safety (S)-phrases are no longer used. The new classification system uses hazard (H)-statements and precautionary (P)-statements. A few new “poison center” P-statements are shown.¹

Fig. 3. From the old classification according to Directive 67/548/EEC to the new classification according to the CLP Regulation (EC) No 1272/2008 (entered into force from January 20, 2009) for the CLP hazard class “acute toxicity oral” (see legend of Fig. 1. for risk (R)‐phrase explanation).^1,7

Table 1.  Translation of the EAPCCT requirements on product composition in terms of the classification of the CLP Regulation (EC) No 1272/2008^1,7

CLP Regulation (EC) No 1272/2008		Approach 1 EAPCCT proposal (direct translation)^a	Approach 2 Division based on CLP pictograms^b	Approach 3 Division based on CLP signal word^c
Hazard class	Categories
Acute toxicity oral	1, 2, 3, 4	1, 2, 3 (partial)	1, 2, 3	1, 2, 3
Acute toxicity dermal	1, 2, 3, 4	1, 2, 3 (partial)	1, 2, 3	1, 2, 3
Acute toxicity inhalation	1, 2, 3, 4	1, 2, 3	1, 2, 3	1, 2, 3
STOT – single exposure	1, 2, 3	1	1, 2	1
STOT – repeated exposure	1, 2	1	1, 2	1
Aspiration hazard	1		1	1
Skin corrosion/irritation	1ABC, 2	1ABC	1ABC	1ABC
Eye damage/irritation	1, 2		1	1
Respiratory sensitization	1		1	1
Skin sensitization	1
Carcinogenicity	1AB, 2	1AB	1AB, 2	1AB
Germ cell mutagenicity	1AB, 2	1AB	1AB, 2	1AB
Reproductive toxicity	1AB, 2	1AB	1AB, 2	1AB
Effects on or via lactation

STOT: specific target organ toxicity.

^aBased on cutoff limits for T⁺, T, and C as used in 67/548/EEC.

^bPictograms: skull and crossbones, health hazard, corrosion.

^cSignal word: danger.

Regulation (EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending Regulation (EC) No 1907/2006. http://eur-lex.europa.eu/Notice.do?val=486098:cs&lang=en&list=490877:cs,486098:cs,&pos=2&page=1&nbl=2&pgs=10&hwords. Accessed 1 December 2009.

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DRAFT Comparison between EU and GHS criteria Human Health and Environment, December 2007. http://ec.europa.eu/enterprise/sectors/chemicals/files/ghs/ghs_comparison_classifications_dec07_en.pdf. Accessed 1 December 2009.

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