Elevated plasma levels of TIMP-1 in patients with rotator cuff tear

Figures & data

Table 1. Plasma levels (ng/mL) in patients with rotator cuff tears and controls. Values are median (range) within each group

	All tears, partial- and full-thickness	Partial-thickness n = 7	Full-thickness n = 10	Controls n = 16
MMP-1	0.5 (0.1–1.8)	0.5 (0.2–1.8)	0.7 (0.1–1.1)	0.3 (0.1–2.0)
MMP-2	232 (155–316)	223 (155–316)	248 (183–283)	246 (138–270)
MMP-3	25 (6.6–43)	17 (14–43)	25 (6.6–35)	22 (5.3–35)
MMP-7	1.2 (0.4–2.7)	1.2 (0.6–1.5)	1.1 (0.4–2.7)	1.2 (0.3–4.2)
MMP-9	48 (30–220)	42 (30–123)	70 (38–220) ^b	48 (7–111)
TIMP-1	86 (67–119) ^a	79 (67–97)	88 (78–119) ^a, c	78 (66–93)
TIMP-2	114 (74–182)	101 (74–182)	116 (87–154)	119 (71–183)
TIMP-3	1.6 (0.9–2.9)	1.3 (0.9–1.9)	2.2 (0.9–2.9) ^b	1.5 (0.7–4.7)
TIMP-4	2.1 (1.6–4.6)	2.4 (1.6–4.7)	2.0 (1.6–2.6)	1.8 (1.2–3.3)

^a Significantly different from controls (p < 0.05).

^b Significantly different from partial-thickness tears (p < 0.05).

^c p = 0.055.

MMP: matrix metalloproteinases; TIMP: tissue inhibitor of metalloproteinases.

Figure 1. Plasma levels (in ng/mL) of TIMP-1, TIMP-3, and MMP-9 in controls, in patients with partial-thickness tears (PTT), and in patients with full-thickness tears (FTT), as measured by multiplex analysis. â—� Outlier (more than one and a half box lengths away). â—� Extreme outlier (more than three box lengths away).

Figure 2. Plasma levels (in ng/mL) of TIMP-1 in controls, in patients with partial-thickness tears (PTT), and in patients with full-thickness tears (FTT), as measured by ELISA. â—� Outlier (more than one and a half box lengths away).

Table 2. Difference between all tears (partial-thickness and full-thickness) and controls. Median value for difference is measured in percent with 95% CI, based on non-parametric statistics

	Median (%)	95% CI
MMP-1	58	-18 to125
MMP-2	0.9	-13 to 11
MMP-3	8	-25 to 33
MMP-7	17	-50 to 19
MMP-9	15	-25 to 66
TIMP-1	10	1 to 26
TIMP-2	2	-19 to 22
TIMP-3	6	-29 to 37
TIMP-4	11	-9 to 38

MMP and TIMP, see Table 1