Figures & data
Figure 1. Histopathological features in the CHOL group (×40). Accumulation of bone marrow cell debris was observed, in addition to bone trabeculae showing empty lacunae in the necrotic areas (Nec). 2 weeks after steroid administration in the CHOL group, neither granulation tissue nor appositional bone formation was obvious between the necrotic areas and living bone marrow tissue (Liv).
Figure 2. Sequential changes in serum lipid levels. The data are mean with standard error bars. The levels of total cholesterol (TC) and ratios of low-density lipoprotein to high-density lipoprotein (LDL/HDL ratios) were different between the CHOL group and the CTR group (both p < 0.001, repeated MANOVA). a. The mean level of TC in the CHOL group increased from week 0 to week 2 (p < 0.001, Wilcoxon signed-rank test). Following methylprednisolone acetate (MPSL) injection, the mean level of TC increased in both groups (both p < 0.001). However, the mean levels of TC in the 2 groups were different at weeks 1, 2, 3, and 4 (p < 0.001). b. The mean LDL/HDL ratio in the CHOL group increased from week 0 to week 2 and also increased from week 2 to week 4 (both p < 0.001, Wilcoxon signed-rank test). There were no statistically significant changes in the CTR group. Thus, the LDL/HDL ratios in the 2 groups were different at weeks 1, 2, 3, and 4 (p < 0.001).
