Expression of gap junction proteins connexins 26, 30, and 43 in Dupuytren’s disease

Figures & data

Table 1. Demographic data on patients with Dupytren’s disease and carpal tunnel syndrome

	Dupytren’s		Controls ^a
	Involutional phase	Residual phase
Number	14	17	9
Sex, F / M	2 / 12	4 / 13	6 / 3
Mean age (SD)	54 (11)	61 (12)	62 (109)
(range), years	(33–71)	(39–81)	(44–79)
Iselin classification
Stage I	3/14	3/17
Stage II	3/14	5/17
Stage III	6/14	7/17
Stage IV	3/14	2/17

^a Carpal tunnel syndrome

Immunohistochemical expression of α-SMA (a, b, c); Cx26 (d, e, f); Cx43 (g, h, i), and Cx30 (j, k, l) in tissue sections from the involutional phase of DD (a, d, g, j); in tissue sections from the residual phase of DD (b, e, h, k), and in tissue sections from controls (patients with carpal tunnel syndrome) (c, f, i, l) (magnification 400×).

Table 2. Numbers of Cx26-, Cx30-, and Cx43-positive cases in the proliferative and residual phase and in controls

Protein	n	Cx26	Cx30	Cx43
Involutional phase (α-SMA positive)	14	12/14 ^a, c	7/14 ^b, d	12/14 ^a, c
Residual phase (α-SMA negative)	17	4/17 ^a	0/17 ^b	3/17 ^a
Controls	7	0 ^c	0 ^d	0 ^c

Statistically significant between Luck’s involutional and residual phases: ^a (p = 0.001), ^b (p = 0.03).

Statistically significant between Luck’s involutional phase and controls: ^c (p = 0.01), ^d (p = 0.02).