Different effects of indomethacin on healing of shaft and metaphyseal fractures

Figures & data

Figure 1. MicroCT images showing volume of interest (VOI) of diaphyseal and metaphyseal fractures. Median specimens from each control group, in terms of bone volume

Figure 2. Force at failure with and without indomethacin in a shaft fracture model and a metaphyseal fracture model.

Table 1. Mechanical evaluation. Values are mean (SD)

		Force at failure N	Stiffness N/mm
Shaft	Indomethacin	4.0 (1.0)	4.6 (2.6)
	Control	6.0 (1.5)	6.6 (2.4)
Metaphysis	Indomethacin	4.3 (1.0)	1.3 (0.33)
	Control	4.1 (1.2)	1.3 (0.40)

Figure 3. Amount of new-formed bone in a shaft fracture model and a metaphyseal fracture model. Indomethacin led to a significant decrease in new-formed bone (by 33% in the shaft and by 12% in the metaphysis).

Table 2. Data from microCT. Values are mean (SD)

		BV, mm^3	TV, mm^3	BV/TV, %	BMD, g/cm^3	Tb.N	Tb.Th, µm	Tb.Sp, µm
Shaft	Indomethacin	4.7 (1.2)	11 (3.3)	43 (4.4)	0.26 (0.032)	-	-	-
Control	7.1 (1.4)	17 (3.7)	43 (3.7)	0.26 (0.028)	-	-	-
Metaphysis	Indomethacin	0.11 (0.015)	0.19 (0.001)	55 (7.7)	0.31 (0.055)	13 (2.0)	43 (2.8)	35 (3.8)
Control	0.12 (0.0050)	0.19 (0.001)	62 (2.6)	0.36 (0.031)	15 (0.55)	43 (1.1)	31 (1.1)